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Hsf [cytosol]
Stable Identifier
R-DME-3371452
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
HSF1, P22813
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to heat stress (Drosophila melanogaster)
HSF1 activation (Drosophila melanogaster)
Dissociation of cytosolic HSF1:HSP90 complex (Drosophila melanogaster)
HSF1:HSP90:PTGES3 [cytosol] (Drosophila melanogaster)
Hsf [cytosol] (Drosophila melanogaster)
Hsf [cytosol] (Drosophila melanogaster)
Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Drosophila melanogaster)
HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] (Drosophila melanogaster)
Hsf [cytosol] (Drosophila melanogaster)
Hsf [cytosol] (Drosophila melanogaster)
Trimerization of cytosolic HSF1 (Drosophila melanogaster)
Hsf [cytosol] (Drosophila melanogaster)
Regulation of HSF1-mediated heat shock response (Drosophila melanogaster)
Constitutive phosphorylation by pERK1/2 (Drosophila melanogaster)
Hsf [cytosol] (Drosophila melanogaster)
Constitutive phosphorylation by GSK3 (Drosophila melanogaster)
Hsf [cytosol] (Drosophila melanogaster)
MAPKAPK2 phosphorylates HSF1 (Drosophila melanogaster)
Hsf [cytosol] (Drosophila melanogaster)
Mitochondrial unfolded protein response (UPRmt) (Drosophila melanogaster)
HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization (Drosophila melanogaster)
Hsf [cytosol] (Drosophila melanogaster)
Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1 (Drosophila melanogaster)
HSF1:HSPA1A,B [cytosol] (Drosophila melanogaster)
Hsf [cytosol] (Drosophila melanogaster)
Hsf [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P22813
Gene Names
Hsf
Reference Genes
BioGPS Gene:37068 Hsf
CTD Gene:37068 Hsf
ENSEMBL:FBgn0001222
FlyBase:FBgn0001222
KEGG:dme:Dmel_CG5748 Hsf
Monarch:37068 Hsf
NCBI Gene:37068 Hsf
UCSC:P22813 Hsf
Reference Transcript
RefSeq:NM_057227.5 Hsf
Other Identifiers
141526_at
1626844_at
37068
GO:0000785
GO:0000978
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005694
GO:0005700
GO:0006355
GO:0006357
GO:0009408
GO:0042742
GO:0042802
GO:0043565
GO:0045892
GO:0045893
GO:0045944
GO:0050832
GO:0098542
Participates
as an input of
MAPKAPK2 phosphorylates HSF1 (Drosophila melanogaster)
Constitutive phosphorylation by GSK3 (Drosophila melanogaster)
Constitutive phosphorylation by pERK1/2 (Drosophila melanogaster)
Trimerization of cytosolic HSF1 (Drosophila melanogaster)
HSF1 is activated by phosphorylation, translocation to the nucleus, and trimerization (Drosophila melanogaster)
as an output of
Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Drosophila melanogaster)
Dissociation of cytosolic HSF1:HSP90 complex (Drosophila melanogaster)
Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1 (Drosophila melanogaster)
as a component of
HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] (Drosophila melanogaster)
HSF1:HSP90:PTGES3 [cytosol] (Drosophila melanogaster)
HSF1:HSPA1A,B [cytosol] (Drosophila melanogaster)
Other forms of this molecule
phospho-Hsf [cytosol]
phospho-Hsf [cytosol]
phospho-Hsf [cytosol]
phospho-Hsf [cytosol]
Hsf [nucleoplasm]
Hsf [cytosol]
phospho-Hsf [nucleoplasm]
Hsf [nucleoplasm]
Hsf [nucleoplasm]
phospho-Hsf [nucleoplasm]
Inferred From
HSF1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_476575.1
ENSEMBL
FBpp0085961
,
FBgn0001222
,
FBtr0086782
FlyBase
FBgn0001222
PRO
P22813
PDB
1HKT
,
1HKS
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:A8DYC5 A8DYC5
0.488
2
UniProt:Q4V4G1 Q4V4G1
0.488
2
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