Reactome | RanGAP [nuclear envelope]

RanGAP [nuclear envelope]

Stable Identifier

R-DME-3000416

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nuclear envelope

Synonyms

monoSUMO1-K524-RANGAP1, Q9VIW3

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle, Mitotic (Drosophila melanogaster)
  - M Phase (Drosophila melanogaster)
    - Mitotic Metaphase and Anaphase (Drosophila melanogaster)
      - Mitotic Anaphase (Drosophila melanogaster)
        
        Nuclear Envelope (NE) Reassembly (Drosophila melanogaster)
        
        Postmitotic nuclear pore complex (NPC) reformation (Drosophila melanogaster)
        
        RAN stimulates fusion of nuclear envelope (NE) membranes (Drosophila melanogaster)
        
        SUMO1:RANGAP1 homodimer [nuclear envelope] (Drosophila melanogaster)
        
        RanGAP [nuclear envelope] (Drosophila melanogaster)

Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - SUMOylation (Drosophila melanogaster)
    - SUMO E3 ligases SUMOylate target proteins (Drosophila melanogaster)
      - SUMOylation of DNA replication proteins (Drosophila melanogaster)
        
        RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Drosophila melanogaster)
        
        RANBP2:RANGAP1-SUMO1:UBE2I:Nuclear Pore Complex (NPC) [nuclear envelope] (Drosophila melanogaster)
        
        RANBP2:RANGAP1-SUMO1:UBE2I [nuclear envelope] (Drosophila melanogaster)
        
        RanGAP [nuclear envelope] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VIW3

Gene Names

RanGAP

Reference Genes

BioGPS Gene:35223 RanGAP

CTD Gene:35223 RanGAP

ENSEMBL:FBgn0003346

FlyBase:FBgn0003346

KEGG:dme:Dmel_CG9999 RanGAP

Monarch:35223 RanGAP

NCBI Gene:35223 RanGAP

UCSC:Q9VIW3 RanGAP

Reference Transcript

Other Identifiers

153879_at

1623819_at

35223

GO:0003723

GO:0005096

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006611

GO:0006886

GO:0006913

GO:0007165

GO:0016020

GO:0022414

GO:0031267

GO:0031965

GO:0045132

GO:0046822

GO:0048471

GO:0051168

GO:0098772

Participates

as a component of

Other forms of this molecule

RanGAP [nuclear envelope]

Inferred From

monoSUMO1-K524-RANGAP1 [nuclear envelope] (Homo sapiens)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 524 (in Homo sapiens)

Coordinate

524

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001260578.1, NP_476712.1

ENSEMBL

FBtr0334174, FBgn0003346, FBpp0080775, FBtr0081234, FBpp0306291

FlyBase

FBgn0003346

PRO

Q9VIW3

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