RDX binds to and ubiquitinates CI

Stable Identifier
R-DME-216283
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RDX binds to and ubiquitinates CI
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
HIB or Roadkill (RDX) is transcriptionally induced by Hedgehog signalling and binds directly to Cubitus Interruptus (CI), likely in competition with Supressor of Fused (SU(FU)), to link CI with a Cul3 aka guftagu (GFT)-based E3 ubiquitin ligase complex, leading to degradation of active nuclear CI.
Literature References
PubMed ID Title Journal Year
16651542 Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus

Kent, D, Bush, EW, Hooper, JE

Development 2006
15331761 Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases

Donaldson, TD, Noureddine, MA, Reynolds, PJ, Bradford, W, Duronio, RJ

Mol Biol Cell 2004
17102630 Regulation of Hh/Gli signaling by dual ubiquitin pathways

Jiang, J

Cell Cycle 2006
16740475 A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor

Zhang, Q, Zhang, L, Wang, B, Ou, CY, Chien, CT, Jiang, J

Dev Cell 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of RDX:GFT:ROC1B [nucleoplasm]

Physical Entity
RDX:GFT:ROC1B [nucleoplasm] (Drosophila melanogaster)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Authored
Williams, MG  (2006-12-07)
Reviewed
Kalderon, D  (2008-03-17)
Created
Williams, MG  (2008-03-11)
Cite Us!