Ubiquitinated CI is degraded by the proteasome complex

Stable Identifier
R-DME-216282
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
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Ubiquitinated CI is degraded by the proteasome complex
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The ubiquitinated Cubitus Interruptus (CI) is marked for degradation in the nucleus by the 26S proteasome complex.
Literature References
PubMed ID Title Journal Year
16651542 Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus

Kent, D, Bush, EW, Hooper, JE

Development 2006
17102630 Regulation of Hh/Gli signaling by dual ubiquitin pathways

Jiang, J

Cell Cycle 2006
16740475 A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor

Zhang, Q, Zhang, L, Wang, B, Ou, CY, Chien, CT, Jiang, J

Dev Cell 2006
Participants
Input
Output
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as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Physical Entity
26S proteasome [nucleoplasm] (Drosophila melanogaster)
Activity
endopeptidase activity (GO:0004175)
Authored
Williams, MG  (2006-12-07)
Reviewed
Kalderon, D  (2008-03-17)
Created
Williams, MG  (2008-03-11)
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