CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex'

Stable Identifier
R-DME-214860
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex'
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Pelle (PLL) may be the kinase that phosphorylates both Cactus (CACT) and the Dorsal/Dorsal-related immunity factor (DL/DIF) homodimer but the biochemical evidence for this is currently inconclusive. DL/DIF homodimer is phosphorylated while associated with CACT. DL is phosphorylated on Ser317 while DIF is very likely to be phosphorylated at Ser348 (inferred from DL). CACT is phosphorylated in its N-terminal half within the first 125 residues. In this region, there are two IKK target-like motifs, involving Ser74 and Ser78 in one, and Ser116 in the other. However, it is not clear which of these residues need to be phosphorylated.
Literature References
PubMed ID Title Journal Year
10072384 Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation

Drier, EA, Huang, LH, Steward, R

Genes Dev 1999
11532919 Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation

Fernandez, NQ, Grosshans, J, Goltz, JS, Stein, D

Development 2001
8948598 A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo

Reach, M, Galindo, RL, Towb, P, Allen, JL, Karin, M, Wasserman, SA

Dev Biol 1996
10660298 Cactus-independent regulation of Dorsal nuclear import by the ventral signal

Drier, EA, Govind, S, Steward, R

Curr Biol 2000
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of unknown kinase [cytosol]

Physical Entity
unknown kinase [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2007-07-11)
Reviewed
Silverman, N  (2008-06-20)
Lemaitre, B  (2008-06-20)
Created
Williams, MG  (2008-02-26)
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