Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'

Stable Identifier
R-DME-214398
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Activated Phospho IRD5:KEY dimer phosphorylates REL in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'
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The Drosophila orthologue of IKKB (IRD5) phosphorylates Relish (REL).
Literature References
PubMed ID Title Journal Year
12732719 Caspase-mediated processing of the Drosophila NF-kappaB factor Relish

Erturk, D, Hedengren-Olcott, M, Silverman, N, Engstrom, Y, Junell, A, Hultmark, D, Maniatis, T, Stoven, S

Proc Natl Acad Sci U S A 2003
11018014 A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity

Pandey, N, Silverman, N, Hultmark, D, Zhou, R, Maniatis, T, Stoven, S

Genes Dev 2000
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Catalyst Activity

protein serine/threonine kinase activity of KEY:Phospho IRD5 dimer:KEY [cytosol]

Physical Entity
KEY:Phospho IRD5 dimer:KEY [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2007-07-11)
Reviewed
Lemaitre, B  (2008-06-20)
Silverman, N  (2008-06-20)
Created
Williams, MG  (2008-02-26)
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