Monomeric PGN bound PGRP-LE oligomerises in the cytosol

Stable Identifier
R-DME-214395
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Monomeric PGN bound PGRP-LE oligomerises in the cytosol
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The binding of monomeric peptidoglycans (PGN) to PGRP-LE receptor results in adjacent PGRP-LE receptors binding to the complex and forming a PGRP-LE oligomer.
Literature References
PubMed ID Title Journal Year
16767093 PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan

Kaneko, T, Yano, T, Aggarwal, K, Lim, JH, Ueda, K, Oshima, Y, Peach, C, Erturk-Hasdemir, D, Goldman, WE, Oh, BH, Kurata, S, Silverman, N

Nat Immunol 2006
16428381 Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins

Lim, JH, Kim, MS, Kim, HE, Yano, T, Oshima, Y, Aggarwal, K, Goldman, WE, Silverman, N, Kurata, S, Oh, BH

J Biol Chem 2006
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Authored
Williams, MG  (2007-07-11)
Reviewed
Silverman, N  (2008-06-20)
Lemaitre, B  (2008-06-20)
Created
Williams, MG  (2008-02-26)
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