Reactome | CDK8 [nucleoplasm]

CDK8 [nucleoplasm]

Stable Identifier

R-DME-212440

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

Q9VT57

Locations in the PathwayBrowser

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Gene expression (Transcription) (Drosophila melanogaster)

- Epigenetic regulation of gene expression (Drosophila melanogaster)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Drosophila melanogaster)
    - Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Drosophila melanogaster)
      - Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Drosophila melanogaster)
        
        MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Drosophila melanogaster)
        
        Coactivators are recruited to liganded PPARG:RXRA heterodimer (Drosophila melanogaster)
        
        Activated PPARG:RXRA:adipogenesis genes:Nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:ACSL1 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:ADIPOQ gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:AGPAT2 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:ANGPTL4 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:CD36 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:CEBPA gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:CIDEC gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:DGAT2 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:FABP4 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:LIPE gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:LPIN1 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:LPL gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:MGLL gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:PDK4 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:PEX11A gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:PLIN1 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:PLIN2 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:PLIN4 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:PNPLA2 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:PPARG gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated PPARG:RXRA:SCD gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated p-Y78,Y102-PPARG2:RXRA:ACSS3 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated p-Y78,Y102-PPARG2:RXRA:ELOVL5 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated p-Y78,Y102-PPARG2:RXRA:GPAM gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated p-Y78,Y102-PPARG2:RXRA:SCD5 gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        Activated p-Y78,Y102-PPARG2:RXRA:THRSP gene:nucleosomes [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
        
        TRAP coactivator complex [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)
- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Drosophila melanogaster)
        
        CDK8:CCNC [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by TGFB family members (Drosophila melanogaster)
  - Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Drosophila melanogaster)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Drosophila melanogaster)
        
        CDK8:CCNC [nucleoplasm] (Drosophila melanogaster)
        
        CDK8 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VT57

Reference Genes

BioGPS Gene:39157

ENSEMBL:FBgn0015618

FlyBase:FBgn0015618

KEGG:dme:Dmel_CG10572

Monarch:39157

NCBI Gene:39157

UCSC:Q9VT57

Reference Transcript

RefSeq:NM_080487.4

Other Identifiers

142743_at

1630579_at

39157

GO:0000082

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004693

GO:0005515

GO:0005524

GO:0005634

GO:0006355

GO:0006357

GO:0006468

GO:0008353

GO:0016073

GO:0016301

GO:0016592

GO:0016740

GO:0022416

GO:0034472

GO:0036011

GO:0045498

GO:0048856

GO:0051726

GO:0106310

GO:0140096

GO:1990508

Participates

as a component of

Inferred From

CDK8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_536735.2

ENSEMBL

FBtr0076369, FBpp0076098, FBgn0015618

FlyBase

FBgn0015618

PRO

Q9VT57

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