Reactome | Caf1-55 [nucleoplasm]

Caf1-55 [nucleoplasm]

Stable Identifier

R-DME-212223

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

RBBP4, Q24572

Locations in the PathwayBrowser

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Cell-Cell communication (Drosophila melanogaster)

- Cell junction organization (Drosophila melanogaster)
  - Cell-cell junction organization (Drosophila melanogaster)
    - Adherens junctions interactions (Drosophila melanogaster)
      - Regulation of Homotypic Cell-Cell Adhesion (Drosophila melanogaster)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Drosophila melanogaster)
        
        Regulation of CDH1 Expression and Function (Drosophila melanogaster)
        
        Regulation of CDH1 Gene Transcription (Drosophila melanogaster)
        
        Negative Regulation of CDH1 Gene Transcription (Drosophila melanogaster)
        
        PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter (Drosophila melanogaster)
        
        PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
        
        Caf1-55 [nucleoplasm] (Drosophila melanogaster)
        
        PRC2 (EZH2) Core:H3K27me3-Nucleosome:CDH1 gene [nucleoplasm] (Drosophila melanogaster)
        
        PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
        
        Caf1-55 [nucleoplasm] (Drosophila melanogaster)
        
        PRC2 (EZH2) Core:Nucleosome:CDH1 gene [nucleoplasm] (Drosophila melanogaster)
        
        PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
        
        Caf1-55 [nucleoplasm] (Drosophila melanogaster)

Immune System (Drosophila melanogaster)

- Adaptive Immune System (Drosophila melanogaster)
  - Regulation of T cell activation by CD28 family (Drosophila melanogaster)
    - Co-inhibition by PD-1 (Drosophila melanogaster)
      - Regulation of PD-L1(CD274) expression (Drosophila melanogaster)
        
        Regulation of PD-L1(CD274) transcription (Drosophila melanogaster)
        
        Trimethylation of CD274 gene promoter by EZH2 (Drosophila melanogaster)
        
        PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
        
        Caf1-55 [nucleoplasm] (Drosophila melanogaster)
        
        PRC2(EZH2) Core:Nucleosome:CD274 gene promoter [nucleoplasm] (Drosophila melanogaster)
        
        PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
        
        Caf1-55 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q24572

Gene Names

Caf1-55

Reference Genes

BioGPS Gene:41836 Caf1-55

CTD Gene:41836 Caf1-55

ENSEMBL:FBgn0263979

FlyBase:FBgn0263979

KEGG:dme:Dmel_CG4236 Caf1-55

Monarch:41836 Caf1-55

NCBI Gene:41836 Caf1-55

UCSC:Q24572 Caf1-55

Reference Transcript

RefSeq:NM_079630.4 Caf1-55

Other Identifiers

154659_at

1626522_at

41836

GO:0000122

GO:0000976

GO:0005515

GO:0005634

GO:0005667

GO:0005694

GO:0005700

GO:0006325

GO:0006335

GO:0006338

GO:0006355

GO:0007307

GO:0007346

GO:0007379

GO:0016581

GO:0016589

GO:0022414

GO:0031491

GO:0031507

GO:0031523

GO:0033186

GO:0034728

GO:0035097

GO:0035098

GO:0042393

GO:0042803

GO:0042826

GO:0045892

GO:0045893

GO:0070822

GO:0090575

GO:0140718

Participates

as a member of

DCAF protein [nucleoplasm] (Drosophila melanogaster)

as a component of

as an input of

Inferred From

RBBP4,7 [nucleoplasm] (Homo sapiens)

RBBP7 [nucleoplasm] (Homo sapiens)

RBBP4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_524354.1

ENSEMBL

FBgn0263979, FBpp0082511, FBtr0083052

FlyBase

FBgn0263979

PRO

Q24572

PDB

2XYI, 3C9C, 2YB8, 2YBA, 3C99

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q24338 ESC			0.876	11
UniProt:P42124	2	E(z) [nucleoplasm] (R-DME-1183229) E(z) [nucleoplasm] (R-DME-212298)	0.833	7
UniProt:P04197 MYB			0.744	6
UniProt:Q9W542	1	mip130 [nucleoplasm] (R-DME-389108)	0.708	7
UniProt:Q94517 HDAC1	3	RPD3 [nucleoplasm] (R-DME-354293) HDAC1 [nucleoplasm] (R-DME-205021) HDAC1 [nucleoplasm] (R-DME-205135)	0.688	4
UniProt:A1Z9E2	1	mip120 [nucleoplasm] (R-DME-389103)	0.669	6
UniProt:Q24459 PCL			0.662	4
UniProt:Q9V6Q2 CID			0.653	6
UniProt:Q9VNF6 Q9VNF6			0.564	2
UniProt:Q9VF04	19	Rbf2 [nucleoplasm] (R-DME-389104-2) Rbf2 [nucleoplasm] (R-DME-68642-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687347-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687351-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687355-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687354-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687353-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687352-2) phospho-Rbf2 [nucleoplasm] (R-DME-69226-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687357-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687356-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687335-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687334-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687339-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687336-2) phospho-Rbf2 [nucleoplasm] (R-DME-9687343-2) Rbf2 [cytosol] (R-DME-9660621-2) phospho-Rbf2 [nucleoplasm] (R-DME-188389-2) phospho-Rbf2 [nucleoplasm] (R-DME-1226085-2)	0.558	4
UniProt:Q24472 Rbf	20	Rbf [nucleoplasm] (R-DME-389104) Rbf [nucleoplasm] (R-DME-389102) Rbf [nucleoplasm] (R-DME-68642) phospho-Rbf [nucleoplasm] (R-DME-9687347) phospho-Rbf [nucleoplasm] (R-DME-9687351) phospho-Rbf [nucleoplasm] (R-DME-9687355) phospho-Rbf [nucleoplasm] (R-DME-9687354) phospho-Rbf [nucleoplasm] (R-DME-9687353) phospho-Rbf [nucleoplasm] (R-DME-9687352) phospho-Rbf [nucleoplasm] (R-DME-69226) phospho-Rbf [nucleoplasm] (R-DME-9687357) phospho-Rbf [nucleoplasm] (R-DME-9687356) phospho-Rbf [nucleoplasm] (R-DME-9687335) phospho-Rbf [nucleoplasm] (R-DME-9687334) phospho-Rbf [nucleoplasm] (R-DME-9687339) phospho-Rbf [nucleoplasm] (R-DME-9687336) phospho-Rbf [nucleoplasm] (R-DME-9687343) Rbf [cytosol] (R-DME-9660621) phospho-Rbf [nucleoplasm] (R-DME-1226084) phospho-Rbf [nucleoplasm] (R-DME-188389)	0.558	4

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