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Caf1-55 [nucleoplasm]
Stable Identifier
R-DME-212223
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
RBBP4, Q24572
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
G0 and Early G1 (Drosophila melanogaster)
Phosphorylation of LIN52 component of MuvB by DYRK1A (Drosophila melanogaster)
MuvB complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
p-MuvB complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
p130 (RBL2) associates with MuvB to form DREAM complex (Drosophila melanogaster)
DREAM complex [nucleoplasm] (Drosophila melanogaster)
p-MuvB complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
p-MuvB complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular Senescence (Drosophila melanogaster)
Oxidative Stress Induced Senescence (Drosophila melanogaster)
Formation of PRC2-EZH2 complex (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
Chromatin organization (Drosophila melanogaster)
Chromatin modifying enzymes (Drosophila melanogaster)
HATs acetylate histones (Drosophila melanogaster)
Type B histone acetlytransferase complex acetylates histone H4 (Drosophila melanogaster)
HAT1:RBBP7 [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
HDACs deacetylate histones (Drosophila melanogaster)
HDAC1:2-containing complex binds HDAC2 Inhibitors (Drosophila melanogaster)
HDAC1:2-containing complex [nucleoplasm] (Drosophila melanogaster)
NuRD complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
Sin3A complex [nucleoplasm] (Drosophila melanogaster)
Sin3a core complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Drosophila melanogaster)
HDAC1:2-containing complex [nucleoplasm] (Drosophila melanogaster)
NuRD complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
Sin3A complex [nucleoplasm] (Drosophila melanogaster)
Sin3a core complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
HDAC1:2-containing complex deacetylate histones (Drosophila melanogaster)
HDAC1:2-containing complex [nucleoplasm] (Drosophila melanogaster)
NuRD complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
Sin3A complex [nucleoplasm] (Drosophila melanogaster)
Sin3a core complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Drosophila melanogaster)
HDAC1:2-containing complex [nucleoplasm] (Drosophila melanogaster)
NuRD complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
Sin3A complex [nucleoplasm] (Drosophila melanogaster)
Sin3a core complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
Epigenetic regulation of gene expression (Drosophila melanogaster)
PRC2 methylates histones and DNA (Drosophila melanogaster)
DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 (Drosophila melanogaster)
DNMT1,3A,3B:PRC2:Chromatin (5-mC, H3K27me3) [nucleoplasm] (Drosophila melanogaster)
PRC2:Chromatin (5-methylcytosine, H3K27me3) [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Drosophila melanogaster)
PRC2 Core:Chromatin [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2 trimethylates histone H3 at lysine-27 (Drosophila melanogaster)
PRC2:Chromatin (H3K27me3) [nucleoplasm] (Drosophila melanogaster)
PRC2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:JARID2:MTF2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF1 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF19 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:Chromatin [nucleoplasm] (Drosophila melanogaster)
PRC2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:JARID2:MTF2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF1 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF19 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin (Drosophila melanogaster)
PRC2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:JARID2:MTF2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF1 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF19 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:Chromatin [nucleoplasm] (Drosophila melanogaster)
PRC2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core:AEBP2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:JARID2:MTF2 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF1 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2:PHF19 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by E2F6 (Drosophila melanogaster)
E2F6:TFDP1:EPC1 binds the PRC2 complex (Drosophila melanogaster)
E2F6:TFDP1:EPC1:PRC2 (EZH2) core [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
Regulation of TP53 Activity (Drosophila melanogaster)
Regulation of TP53 Activity through Acetylation (Drosophila melanogaster)
MTA2-NuRD complex deacetylates TP53 (Drosophila melanogaster)
MTA2-NuRD complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Drosophila melanogaster)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Drosophila melanogaster)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Drosophila melanogaster)
DCAF protein [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Drosophila melanogaster)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Drosophila melanogaster)
DCAF protein [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Drosophila melanogaster)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Drosophila melanogaster)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Drosophila melanogaster)
DCAF protein [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Drosophila melanogaster)
DCAF protein [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Drosophila melanogaster)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Drosophila melanogaster)
DCAF protein [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Drosophila melanogaster)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Drosophila melanogaster)
DCAF protein [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Drosophila melanogaster)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Drosophila melanogaster)
DCAF protein [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Drosophila melanogaster)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Drosophila melanogaster)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Drosophila melanogaster)
DCAF protein [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
PTEN Regulation (Drosophila melanogaster)
Regulation of PTEN gene transcription (Drosophila melanogaster)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Drosophila melanogaster)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Drosophila melanogaster)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Drosophila melanogaster)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
SALL4 recruits NuRD to PTEN gene (Drosophila melanogaster)
NuRD complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
SALL4:NuRD:PTEN gene [nucleoplasm] (Drosophila melanogaster)
SALL4:NuRD [nucleoplasm] (Drosophila melanogaster)
NuRD complex [nucleoplasm] (Drosophila melanogaster)
Caf1-55 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q24572
Gene Names
Caf1-55
Reference Genes
BioGPS Gene:41836 Caf1-55
CTD Gene:41836 Caf1-55
ENSEMBL:FBgn0263979
FlyBase:FBgn0263979
KEGG:dme:Dmel_CG4236 Caf1-55
Monarch:41836 Caf1-55
NCBI Gene:41836 Caf1-55
UCSC:Q24572 Caf1-55
Reference Transcript
RefSeq:NM_079630.4 Caf1-55
Other Identifiers
154659_at
1626522_at
41836
GO:0000122
GO:0000976
GO:0003677
GO:0005515
GO:0005634
GO:0005667
GO:0005694
GO:0005700
GO:0006325
GO:0006335
GO:0006338
GO:0006355
GO:0007307
GO:0007346
GO:0007379
GO:0016575
GO:0016581
GO:0016589
GO:0022414
GO:0031491
GO:0031507
GO:0031523
GO:0033186
GO:0034728
GO:0035097
GO:0035098
GO:0042393
GO:0042803
GO:0042826
GO:0043226
GO:0045892
GO:0045893
GO:0070822
GO:0090575
GO:0140718
Participates
as a member of
DCAF protein [nucleoplasm] (Drosophila melanogaster)
as a component of
Sin3a core complex [nucleoplasm] (Drosophila melanogaster)
HAT1:RBBP7 [nucleoplasm] (Drosophila melanogaster)
MTA2-NuRD complex [nucleoplasm] (Drosophila melanogaster)
PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
NuRD complex [nucleoplasm] (Drosophila melanogaster)
p-MuvB complex [nucleoplasm] (Drosophila melanogaster)
MuvB complex [nucleoplasm] (Drosophila melanogaster)
as an input of
Formation of PRC2-EZH2 complex (Drosophila melanogaster)
Inferred From
RBBP4,7 [nucleoplasm]
(Homo sapiens)
RBBP7 [nucleoplasm]
(Homo sapiens)
RBBP4 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_524354.1
ENSEMBL
FBgn0263979
,
FBpp0082511
,
FBtr0083052
FlyBase
FBgn0263979
PRO
Q24572
PDB
3C99
,
2YBA
,
2YB8
,
3C9C
,
2XYI
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q24338 ESC
0.876
11
UniProt:P42124
1
E(z) [nucleoplasm]
(R-DME-212298)
0.833
7
UniProt:P04197 MYB
0.744
6
UniProt:Q9W542
1
mip130 [nucleoplasm]
(R-DME-389108)
0.708
7
UniProt:Q94517 Rpd3
3
RPD3 [nucleoplasm]
(R-DME-354293)
HDAC1 [nucleoplasm]
(R-DME-205021)
HDAC1 [nucleoplasm]
(R-DME-205135)
0.688
4
UniProt:A1Z9E2
1
mip120 [nucleoplasm]
(R-DME-389103)
0.669
6
UniProt:Q24459 PCL
0.662
4
UniProt:Q9V6Q2 CID
0.653
6
UniProt:Q9VNF6 Q9VNF6
0.564
2
UniProt:Q9VF04
2
phospho-Rbf2 [nucleoplasm]
(R-DME-1226085-2)
Rbf2 [nucleoplasm]
(R-DME-389104-2)
0.558
4
UniProt:Q24472 Rbf
5
dRb1 protein [nucleoplasm]
(R-DME-113647)
phospho-Rbf [nucleoplasm]
(R-DME-1226085)
phospho-Rbf [nucleoplasm]
(R-DME-1226084)
Rbf [nucleoplasm]
(R-DME-389102)
Rbf [nucleoplasm]
(R-DME-389104)
0.558
4
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