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PAK2 [cytosol]
Stable Identifier
R-DME-211604-2
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
Q9VI13
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
EPH-Ephrin signaling (Drosophila melanogaster)
Ephrin signaling (Drosophila melanogaster)
PAK binds RAC and bPIX (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Drosophila melanogaster)
PAK1/3, 2 [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
PAK1/3, 2 [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
PAKs autophosphorylate (Drosophila melanogaster)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Drosophila melanogaster)
PAK1/3, 2 [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
PAK1/3, 2 [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Regulation of T cell activation by CD28 family (Drosophila melanogaster)
Co-stimulation by CD28 (Drosophila melanogaster)
CD28 dependent Vav1 pathway (Drosophila melanogaster)
Activation of PAKs by RAC1 and CDC42 (Drosophila melanogaster)
PAK1,2,3 [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
PAK1,2,3 dimer [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Drosophila melanogaster)
PAK1,2,3 [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CD209 (DC-SIGN) signaling (Drosophila melanogaster)
PAK phosphorylates p21 RAF1 on S338 (Drosophila melanogaster)
PAK1,2,3 [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated MAPK activation (Drosophila melanogaster)
Autophosphorylation of PAK (Drosophila melanogaster)
PAK dimer [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
PAK dimer [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)
PAK dimer [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
PAK dimer [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK6/MAPK4 signaling (Drosophila melanogaster)
Activation of PAKs by RAC1 and CDC42 (Drosophila melanogaster)
PAK1,2,3 [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
PAK1,2,3 dimer [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Drosophila melanogaster)
PAK1,2,3 [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
Autophosphorylation of PAK1,2,3 (Drosophila melanogaster)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Drosophila melanogaster)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
PAK1-3 autophosphorylates (Drosophila melanogaster)
PAK1,2,3 dimer [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Drosophila melanogaster)
PAK1,2,3 [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
PAK1-3 dimer disassociates (Drosophila melanogaster)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Drosophila melanogaster)
PAK1,2,3 dimer [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Drosophila melanogaster)
PAK1,2,3 [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RAC1 binds PAK1-3 (Drosophila melanogaster)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Drosophila melanogaster)
PAK1,2,3 dimer [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
PAK1,2,3 dimer [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase Effectors (Drosophila melanogaster)
RHO GTPases activate PAKs (Drosophila melanogaster)
Autophosphorylation of PAK1,2,3 (Drosophila melanogaster)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Drosophila melanogaster)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RAC1 and CDC42 activate PAK2 (Drosophila melanogaster)
CDC42:GTP,RAC1:GTP:PAK2 [plasma membrane] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RHO GTPase cycle (Drosophila melanogaster)
RAC1 GTPase cycle (Drosophila melanogaster)
RAC1 binds effectors at the plasma membrane (Drosophila melanogaster)
RAC1 effectors [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RAC1:GTP:RAC1 effectors [plasma membrane] (Drosophila melanogaster)
RAC1 effectors [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RAC3 GTPase cycle (Drosophila melanogaster)
RAC3 binds effectors at the plasma membrane (Drosophila melanogaster)
RAC3 effectors [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RAC3:GTP:RAC3 effectors [plasma membrane] (Drosophila melanogaster)
RAC3 effectors [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RHOH GTPase cycle (Drosophila melanogaster)
RHOH binds effectors at the plasma membrane (Drosophila melanogaster)
RHOH effectors [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RHOH:GTP:RHOH effectors [plasma membrane] (Drosophila melanogaster)
RHOH effectors [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RHOQ GTPase cycle (Drosophila melanogaster)
RHOQ binds effectors at the plasma membrane (Drosophila melanogaster)
RHOQ effectors [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Drosophila melanogaster)
RHOQ effectors [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RHOU GTPase cycle (Drosophila melanogaster)
RHOU binds effectors at the plasma membrane (Drosophila melanogaster)
RHOU effectors [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RHOU:GTP:RHOU effectors [plasma membrane] (Drosophila melanogaster)
RHOU effectors [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RHOV GTPase cycle (Drosophila melanogaster)
RHOV binds effectors at the plasma membrane (Drosophila melanogaster)
RHOV effectors [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
RHOV:GTP:RHOV effectors [plasma membrane] (Drosophila melanogaster)
RHOV effectors [cytosol] (Drosophila melanogaster)
PAK2 dimer [cytosol] (Drosophila melanogaster)
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
PAK2 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VI13 Pak
Gene Names
Pak, DPAK, Dpak1, CG10295
Chain
chain:1-704
Reference Genes
BioGPS Gene:44039 Pak
CTD Gene:44039 Pak
KEGG:dme:Dmel_CG10295 Pak
Monarch:44039 Pak
NCBI Gene:44039 Pak
UCSC:Q9VI13 Pak
Reference Transcript
RefSeq:NM_001275384.1 Pak
RefSeq:NM_169136.3 Pak
RefSeq:NM_169137.3 Pak
RefSeq:NM_001275380.2 Pak
RefSeq:NM_079942.4 Pak
Other Identifiers
153976_at
1634405_s_at
44039
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005925
GO:0006468
GO:0007155
GO:0007391
GO:0007395
GO:0007411
GO:0007480
GO:0009267
GO:0009791
GO:0009887
GO:0012501
GO:0016301
GO:0016328
GO:0016477
GO:0016740
GO:0017124
GO:0019991
GO:0030054
GO:0030424
GO:0030426
GO:0031252
GO:0031267
GO:0031594
GO:0034329
GO:0034330
GO:0035075
GO:0035556
GO:0042995
GO:0043067
GO:0043226
GO:0043408
GO:0045887
GO:0048102
GO:0048598
GO:0048870
GO:0050770
GO:0050803
GO:0070161
GO:0090128
GO:0097482
GO:0098696
GO:0140096
Participates
as a member of
Homologues of PAK2 [cytosol] (Drosophila melanogaster)
Other forms of this molecule
phospho-p-S141,T402-PAK2 [cytosol]
phospho-p-S144,T423-PAK1 [cytosol]
PAK1 [cytosol]
PAK3 [cytosol]
phospho-p-S154,T436-PAK3 [cytosol]
Pak [cytosol]
phospho-p-S141,T402-PAK2 [plasma membrane]
phospho-p-S144,T423-PAK1 [plasma membrane]
phospho-p-S154,T436-PAK3 [plasma membrane]
PAK1 [plasma membrane]
Inferred From
PAK2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_524681.1
,
NP_001262309.1
,
NP_001262313.1
,
NP_731074.1
,
NP_731073.1
ENSEMBL
FBpp0306606
,
FBtr0081716
,
FBtr0081715
,
FBpp0306611
,
FBtr0334544
,
FBpp0081213
,
FBgn0267698
,
FBpp0081212
,
FBtr0081714
,
FBpp0081211
,
FBtr0334539
FlyBase
FBgn0267698
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40792 Rac1
7
RAC1 [endoplasmic reticulum membrane]
(R-DME-5672076)
RAC1 [ficolin-1-rich granule membrane]
(R-DME-6804802)
RAC1 [secretory granule membrane]
(R-DME-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-DME-2316446)
Ub-RAC1 [plasma membrane]
(R-DME-9959460)
RAC1_DROME [cytosol]
(R-DME-428467)
RAC1 [plasma membrane]
(R-DME-351103)
0.766
5
UniProt:Q8IPW2 dock
1
DOCK [cytosol]
(R-DME-179477)
0.635
3
UniProt:P48554
3
RAC3 [endoplasmic reticulum membrane]
(R-DME-9714693)
RAC3 [plasma membrane]
(R-DME-195338)
RAC3 [cytosol]
(R-DME-195335)
0.632
3
UniProt:O44924 robo
1
Robo1_DROME [plasma membrane]
(R-DME-428452)
0.482
5
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