SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription

Stable Identifier
R-DME-209296
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
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SU(VAR)2-10 binds to the phosphorylated STAT92E dimer and inhibits transcription
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The negative pathway regulator SU(VAR)2-10 physically interacts with the phosphorylated STAT92E dimer and prevents it from binding to it's pathway target genes and so inhibiting transcription.

SU(VAR)2-10 is a PIAS protein (protein inhibitors of activated STAT) and is also referred to as ZIMP protein.

In vertebrates, PIAS proteins control the duration of JAK/STAT signalling by targeting active STAT for degradation by SUMOlation.
Literature References
PubMed ID Title Journal Year
9388184 Specific inhibition of Stat3 signal transduction by PIAS3

Chung, CD, Liao, J, Liu, B, Rao, X, Jay, P, Berta, P, Shuai, K

Science 1997
11504941 A Drosophila PIAS homologue negatively regulates stat92E

Betz, A, Lampen, N, Martinek, S, Young, MW, Darnell JE, Jr

Proc Natl Acad Sci U S A 2001
11390354 The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein family

Hari, KL, Cook, KR, Karpen, GH

Genes Dev 2001
10805787 Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction

Liao, J, Fu, Y, Shuai, K

Proc Natl Acad Sci U S A 2000
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Authored
Williams, MG  (2006-11-02)
Reviewed
Perrimon, N  (2008-01-16)
Created
Williams, MG  (2006-11-03)
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