N-HH binds to the transmembrane HSPG proteins

Stable Identifier
R-DME-209272
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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N-HH binds to the transmembrane HSPG proteins
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N-HH movement between cells is facilitated by the glypicans aka heparan sulphate proteoglycan proteins (HSPGs), Dally (DALLY) and Dally-like protein (DLP) which require heparan sulphate modification by the Exostosin (EXT) family proteins tout-velu (TTV), brother of tout-velu (BOTV) and sister of tout-velu (EXT2) for this purpose. N-HH can form multimers, associated with enhanced movement of vertebrate Sonic Hedgehog, and can associate with lipophorin-containing lipophorin particles which appear to enhance N-HH movement. The protein Shifted (SHF) also facilitates HH movement.
Literature References
PubMed ID Title Journal Year
18198278 Patched, the receptor of Hedgehog, is a lipoprotein receptor

Callejo, A, Culi, J, Guerrero, I

Proc Natl Acad Sci U S A 2008
14729575 Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process

Han, C, Belenkaya, TY, Wang, B, Lin, X

Development 2004
11395778 A freely diffusible form of Sonic hedgehog mediates long-range signalling

Zeng, X, Goetz, JA, Suber, LM, Scott WJ, Jr, Schreiner, CM, Robbins, DJ

Nature 2001
10549295 Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan

The, I, Bellaiche, Y, Perrimon, N

Mol Cell 1999
15563523 Functions of heparan sulfate proteoglycans in cell signaling during development

Lin, X

Development 2004
15875013 Lipoprotein particles are required for Hedgehog and Wingless signalling

Panáková, D, Sprong, H, Marois, E, Thiele, C, Eaton, S

Nature 2005
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Authored
Williams, MG  (2006-12-07)
Reviewed
Kalderon, D  (2008-03-17)
Created
Williams, MG  (2006-12-08)
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