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N-HH moves from the cytosol to the extracellular region
Stable Identifier
R-DME-209271
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Drosophila signaling pathways (Drosophila melanogaster)
Hedgehog pathway (Drosophila melanogaster)
Formation and transport of the N-HH ligand (Drosophila melanogaster)
N-HH moves from the cytosol to the extracellular region (Drosophila melanogaster)
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With the help of the transmembrane protein Dispatched (DISP), N-HH is secreted from the cytosol to the extracellular region.
Literature References
PubMed ID
Title
Journal
Year
10619433
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells
Hafen, E
,
Senti, KA
,
Bellotto, M
,
Nellen, D
,
Burke, R
,
Basler, K
,
Dickson, BJ
Cell
1999
Participants
Input
DISP [plasma membrane]
(Drosophila melanogaster)
N-HH [cytosol]
(Drosophila melanogaster)
Output
DISP [plasma membrane]
(Drosophila melanogaster)
N-HH [extracellular region]
(Drosophila melanogaster)
Participates
as an event of
Formation and transport of the N-HH ligand (Drosophila melanogaster)
Authored
Williams, MG (2006-12-07)
Reviewed
Kalderon, D (2008-03-17)
Created
Williams, MG (2006-12-08)
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