Reactome | CI75 inhibits transcription

CI75 inhibits transcription

Stable Identifier

R-DME-209252

Type

Reaction [transition]

Species

Drosophila melanogaster

Compartment

nucleoplasm

ReviewStatus

5/5

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Upon arrival in the nucleus, truncated Cubitus Interruptus (CI75) represses transcription. Sensitive target genes include hh and dpp, but not ptc and repression depends on direct DNA-binding sites for CI75.

Literature References

PubMed ID	Title	Journal	Year
10102270	Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus Methot, N, Basler, K	Cell	1999
9215627	Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor Aza-Blanc, P, Ramirez-Weber, FA, Laget, MP, Schwartz, C, Kornberg, TB	Cell	1997
10862738	The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic gli-binding sites Müller, B, Basler, K	Development	2000