Phosphorylation of CI by PKA-C1

Stable Identifier
R-DME-209196
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of CI by PKA-C1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cubitus Interruptus (CI) is primed for phosphorylation by Protein kinase A (PKA-C1) at Ser838, Ser856, and Ser892.
Literature References
PubMed ID Title Journal Year
10557210 Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus

Wang, G, Wang, B, Jiang, J

Genes Dev 1999
10409506 Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling

Chen, Y, Cardinaux, JR, Goodman, RH, Smolik, SM

Development 1999
9482888 Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus

Chen, Y, Gallaher, N, Goodman, RH, Smolik, SM

Proc Natl Acad Sci U S A 1998
10477300 Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A

Price, MA, Kalderon, D

Development 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of CNK:PHL:Phospho (2 sites) KSR:AVE:DSOR1:CK2:PAR-1:PP2A-29B:MTS [cytosol]

Physical Entity
CNK:PHL:Phospho (2 sites) KSR:AVE:DSOR1:CK2:PAR-1:PP2A-29B:MTS [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2006-12-07)
Reviewed
Kalderon, D  (2008-03-17)
Created
Williams, MG  (2006-12-08)
Cite Us!