Reactome | Further phosphorylation of CI by CKIalphaepsilon

Further phosphorylation of CI by CKIalphaepsilon

Stable Identifier

R-DME-209187

Type

Reaction [transition]

Species

Drosophila melanogaster

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Further phosphorylation of CI by CKIalphaepsilon

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Previous phosphorylation of Cubitus Interruptus (CI) at Ser852 and Ser888 primes further phosphorylation by CKIalphaepsilon (CKIalpha/DCO) at Ser855, Ser858, and Ser891.

Literature References

PubMed ID	Title	Journal	Year
16326393	Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing Jia, J, Zhang, L, Zhang, Q, Tong, C, Wang, B, Hou, F, Amanai, K, Jiang, J	Dev Cell	2005
17925225	Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation Smelkinson, MG, Zhou, Q, Kalderon, D	Dev Cell	2007
11955435	Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1 Price, MA, Kalderon, D	Cell	2002

Participants

Input

Output

Participates

as an event of

Phosphorylation of CI (Drosophila melanogaster)

Catalyst Activity

protein serine/threonine kinase activity of CKIalphaepsilon [cytosol]

Physical Entity

CKIalphaepsilon [cytosol] (Drosophila melanogaster)

Activity

protein serine/threonine kinase activity (GO:0004674)

Authored

Williams, MG (2006-12-07)

Reviewed

Kalderon, D (2008-03-17)

Created

Williams, MG (2006-12-08)

Cite Us!