Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane

Stable Identifier
R-DME-209185
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
plasma membrane
ReviewStatus
5/5
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Monomeric PGN bound PGRP-LCx heterodimerises with PGRP-LCa at the plasma membrane
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Peptidoglycan recognition protein, PGRP-LCa receptor shows only a low affinity for monomeric peptidoglycans (PGN). However, when monomeric PGN binds to PGRP-LCx receptor primarily through its elongated stem peptide, the unique disaccharide GlcNAc-MurNAc(anhydro) residues of the ligand are then presented by PGRP-LCx receptor in such a way as to make favourable interactions with the PGRP-LCa receptor ectodomain. The receptors are now in close proximity and can heterodimerise.
Literature References
PubMed ID Title Journal Year
16556841 Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor

Chang, CI, Chelliah, Y, Borek, D, Mengin-Lecreulx, D, Deisenhofer, J

Science 2006
15843462 Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro

Mellroth, P, Karlsson, J, Hakansson, J, Schultz, N, Goldman, WE, Steiner, H

Proc Natl Acad Sci U S A 2005
16767093 PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan

Kaneko, T, Yano, T, Aggarwal, K, Lim, JH, Ueda, K, Oshima, Y, Peach, C, Erturk-Hasdemir, D, Goldman, WE, Oh, BH, Kurata, S, Silverman, N

Nat Immunol 2006
16006509 Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition

Chang, CI, Ihara, K, Chelliah, Y, Mengin-Lecreulx, D, Wakatsuki, S, Deisenhofer, J

Proc Natl Acad Sci U S A 2005
16428381 Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins

Lim, JH, Kim, MS, Kim, HE, Yano, T, Oshima, Y, Aggarwal, K, Goldman, WE, Silverman, N, Kurata, S, Oh, BH

J Biol Chem 2006
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Authored
Williams, MG  (2007-07-11)
Reviewed
Silverman, N  (2008-06-20)
Lemaitre, B  (2008-06-20)
Created
Williams, MG  (2007-07-12)
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