Phosphorylation of SMO by CKIalpha

Stable Identifier
R-DME-209168
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of SMO by CKIalpha
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Priming phosphorylation of the transmembrane protein Smoothened (SMO) leads to additional phosphorylation by Casein kinase I alpha (CKIalpha) at Ser670, Ser673, Ser690, Ser693, Ser743, and Ser746. Even though SMO has been shown to be explicitly phosphorylated by CKIalpha, phosphorylation of these residues by other CK1 isoforms cannot be ruled out. In addition, other residues are probably phosphorylated by unidentified kinases.
Literature References
PubMed ID Title Journal Year
15598741 Extensive phosphorylation of Smoothened in Hedgehog pathway activation

Zhang, C, Williams, EH, Guo, Y, Lum, L, Beachy, PA

Proc Natl Acad Sci U S A 2004
15592457 Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

Apionishev, S, Katanayeva, NM, Marks, SA, Kalderon, D, Tomlinson, A

Nat Cell Biol 2005
15616566 Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I

Jia, J, Tong, C, Wang, B, Luo, L, Jiang, J

Nature 2004
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Catalyst Activity

protein serine/threonine kinase activity of ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol]

Physical Entity
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2006-12-07)
Reviewed
Kalderon, D  (2008-03-17)
Created
Williams, MG  (2006-12-08)
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