Polymeric PGN bound PGRP-LCx multimerises at the plasma membrane

Stable Identifier
R-DME-209158
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
plasma membrane
ReviewStatus
5/5
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Polymeric PGN bound PGRP-LCx multimerises at the plasma membrane
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The binding of polymeric peptidoglycan (PGN) to PGRP-LCx receptor results in adjacent PGRP-LCx receptors additionally binding to PGN. This brings the receptors into close enough proximity for them to multimerise.
Literature References
PubMed ID Title Journal Year
15843462 Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro

Mellroth, P, Karlsson, J, Hakansson, J, Schultz, N, Goldman, WE, Steiner, H

Proc Natl Acad Sci U S A 2005
15142531 Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway

Kaneko, T, Goldman, WE, Mellroth, P, Steiner, H, Fukase, K, Kusumoto, S, Harley, W, Fox, A, Golenbock, D, Silverman, N

Immunity 2004
15657141 Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor

Choe, KM, Lee, H, Anderson, KV

Proc Natl Acad Sci U S A 2005
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Authored
Williams, MG  (2007-07-11)
Reviewed
Silverman, N  (2008-06-20)
Lemaitre, B  (2008-06-20)
Created
Williams, MG  (2007-07-12)
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