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CKIalpha [cytosol]
Stable Identifier
R-DME-206210
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Circadian Clock pathway (Drosophila melanogaster)
Phosphorylation of PER and TIM (Drosophila melanogaster)
CRY is phosphorylated by SGG (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
PER is phosphorylated by DCO (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Hedgehog pathway (Drosophila melanogaster)
N-HH ligand bound to PTC receptor complex (Drosophila melanogaster)
Activation of SMO (Drosophila melanogaster)
Phosphorylation of SMO (Drosophila melanogaster)
Phosphorylation of SMO by CKIalpha (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
N-HH ligand not bound to PTC receptor complex (Drosophila melanogaster)
Assembly of the CI containing complexes (Drosophila melanogaster)
Formation of the 'scaffold complex' (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
COS:CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phosphorylation of CI (Drosophila melanogaster)
Further phosphorylation of CI by CKIalphaepsilon (Drosophila melanogaster)
CKIalphaepsilon [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
COS:Phospho (13 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
COS:Phospho (16 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO) (Drosophila melanogaster)
CKIalphaepsilon [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
COS:Phospho (11 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
COS:Phospho (3 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phosphorylation of CI by PKA-C1 (Drosophila melanogaster)
COS:CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
COS:Phospho (3 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phosphorylation of CI by SGG (Drosophila melanogaster)
COS:Phospho (11 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
COS:Phospho (13 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Ubiquitination and proteolysis of phosphorylated CI (Drosophila melanogaster)
SLMB binds to and ubiquitinates phosphorylated CI (Drosophila melanogaster)
COS:Phospho (16 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:COS:Phospho (16 sites) CI:UBI-P63E:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:Phospho (16 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex (Drosophila melanogaster)
COS:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:COS:Phospho (16 sites) CI:UBI-P63E:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:Phospho (16 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Wingless pathway (Drosophila melanogaster)
WG ligand bound to FZ receptors (Drosophila melanogaster)
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM (Drosophila melanogaster)
Destabilisation and degradation of AXN in the 'destruction complex' (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
WG ligand not bound to FZ receptors (Drosophila melanogaster)
Assembly of the 'destruction complex' (Drosophila melanogaster)
ARM binds to APC and AXN in the 'destruction complex' (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Formation of the 'destruction complex' (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phosphorylation of ARM (Drosophila melanogaster)
Further phosphorylation of ARM by SGG (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phospho ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phosphorylation of ARM by CKIalpha (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phospho ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phosphorylation of AXN and APC (Drosophila melanogaster)
Further phosphorylation of APC by DCO (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (2 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (5 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Further phosphorylation of APC by SGG (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (5 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phosphorylation of AXN and APC by DCO (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phosphorylation of AXN and APC by SGG (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (2 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
Ubiquitination and degradation of phosphorylated ARM (Drosophila melanogaster)
Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex' (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
SLMB binds to phosphorylated ARM to form the 'destruction complex' (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
SLMB:SKPA:LIN19:ROC1A:EFF:Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
CKIalpha [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P54367 CkIalpha
Gene Names
CkIalpha, CKI, CG2028
Chain
chain:1-337
Reference Genes
BioGPS Gene:32221 CkIalpha
CTD Gene:32221 CkIalpha
KEGG Gene (Drosophila melanogaster):Dmel_CG2028 CkIalpha
Monarch:32221 CkIalpha
NCBI Gene:32221 CkIalpha
UCSC:P54367 CkIalpha
Reference Transcript
RefSeq:NM_001298235.1 CkIalpha
RefSeq:NM_001169266.3 CkIalpha
RefSeq:NM_001298234.1 CkIalpha
RefSeq:NM_078585.6 CkIalpha
RefSeq:NM_167331.4 CkIalpha
RefSeq:NM_167332.3 CkIalpha
Other Identifiers
143778_at
1623403_s_at
32221
GO:0000166
GO:0000902
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006281
GO:0006468
GO:0007165
GO:0016055
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0023052
GO:0030163
GO:0030877
GO:0030949
GO:0032436
GO:0035313
GO:0035331
GO:0036211
GO:0042060
GO:0042593
GO:0043226
GO:0045879
GO:0045880
GO:0048856
GO:0048870
GO:0090090
GO:0106310
GO:0140096
GO:1901800
Participates
as a component of
Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (5 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Phospho (3 sites) AXN:Phospho (2 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
COS:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:Phospho (3 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:Phospho (11 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
COS:Phospho (13 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
COS:Phospho (16 sites) CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] (Drosophila melanogaster)
Phospho (4 sites) ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
as an output of
Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)
as an input of
Formation of the 'destruction complex' (Drosophila melanogaster)
Formation of the 'scaffold complex' (Drosophila melanogaster)
as a member of
CKIalphaepsilon [cytosol] (Drosophila melanogaster)
Other forms of this molecule
CSNK1A1 [cilium]
CSNK1A1 [cytosol]
Cross References
RefSeq
NP_001285163.1
,
NP_001285164.1
,
NP_727632.1
,
NP_511140.1
,
NP_727631.1
,
NP_001162737.1
Flybase
FBgn0015024
PRO
P54367
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18824 arm
20
arm [nucleoplasm]
(R-DME-3451168)
arm [cytosol]
(R-DME-448839)
arm [cytosol]
(R-DME-202930)
arm [cytosol]
(R-DME-202950)
phospho-arm [cytosol]
(R-DME-8942374)
phospho-arm [cytosol]
(R-DME-8942369)
phospho-arm [cytosol]
(R-DME-8942367)
phospho-arm [cytosol]
(R-DME-8942363)
arm [plasma membrane]
(R-DME-9038440)
arm [plasma membrane]
(R-DME-437260)
arm [ficolin-1-rich granule lumen]
(R-DME-6801028)
arm [extracellular region]
(R-DME-6806309)
arm [specific granule lumen]
(R-DME-6799534)
phospho-arm [cytosol]
(R-DME-3134933)
phospho-arm [nucleoplasm]
(R-DME-3134926)
arm [cytosol]
(R-DME-201598)
Phospho (4 sites) ARM [cytosol]
(R-DME-205960)
ARM [cytosol]
(R-DME-205774)
Phospho ARM [cytosol]
(R-DME-206159)
ARM [nucleoplasm]
(R-DME-205878)
0.508
2
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