Reactome | actin:ATP [plasma membrane]

actin:ATP [plasma membrane]

Stable Identifier

R-DME-203000

Type

Complex

Species

Drosophila melanogaster

Compartment

plasma membrane

Locations in the PathwayBrowser

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Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - BAR domain proteins recruit dynamin (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        f-actin [plasma membrane] (Drosophila melanogaster)
        
        actin:ATP [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        f-actin [plasma membrane] (Drosophila melanogaster)
        
        actin:ATP [plasma membrane] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        f-actin [plasma membrane] (Drosophila melanogaster)
        
        actin:ATP [plasma membrane] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        f-actin [plasma membrane] (Drosophila melanogaster)
        
        actin:ATP [plasma membrane] (Drosophila melanogaster)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        f-actin [plasma membrane] (Drosophila melanogaster)
        
        actin:ATP [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        f-actin [plasma membrane] (Drosophila melanogaster)
        
        actin:ATP [plasma membrane] (Drosophila melanogaster)
    - RAB5 and GAPVD1 bind AP-2 (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        f-actin [plasma membrane] (Drosophila melanogaster)
        
        actin:ATP [plasma membrane] (Drosophila melanogaster)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        f-actin [plasma membrane] (Drosophila melanogaster)
        
        actin:ATP [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        f-actin [plasma membrane] (Drosophila melanogaster)
        
        actin:ATP [plasma membrane] (Drosophila melanogaster)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a repeated unit of

f-actin [plasma membrane] (Drosophila melanogaster)

Inferred From

actin:ATP [plasma membrane] (Homo sapiens)

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