Reactome | sl [cytosol]

sl [cytosol]

Stable Identifier

R-DME-202320

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

PLCG1, Q9VXH3

Locations in the PathwayBrowser

Expand all

Immune System (Drosophila melanogaster)

- Innate Immune System (Drosophila melanogaster)
  - DAP12 interactions (Drosophila melanogaster)
    - DAP12 signaling (Drosophila melanogaster)
      - Activation of RAC1 by VAV2/3 (Drosophila melanogaster)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        sl [cytosol] (Drosophila melanogaster)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        sl [cytosol] (Drosophila melanogaster)
  - Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
    - FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
      - Autophosphorylation of BTK/ITK (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        sl [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        sl [cytosol] (Drosophila melanogaster)
    - FCERI mediated MAPK activation (Drosophila melanogaster)
      - Activation of RAC1 by VAV (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        sl [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        sl [cytosol] (Drosophila melanogaster)
      - Autophosphorylation of PAK (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        sl [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        sl [cytosol] (Drosophila melanogaster)
      - Phosphorylation and activation of VAV (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        sl [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        sl [cytosol] (Drosophila melanogaster)
      - Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        sl [cytosol] (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
        
        sl [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VXH3

Gene Names

Reference Genes

BioGPS Gene:32601 sl

CTD Gene:32601 sl

ENSEMBL:FBgn0003416

FlyBase:FBgn0003416

KEGG:dme:Dmel_CG4200 sl

Monarch:32601 sl

NCBI Gene:32601 sl

UCSC:Q9VXH3 sl

Reference Transcript

RefSeq:NM_057378.3 sl

Other Identifiers

153466_at

1628815_at

32601

GO:0004435

GO:0005515

GO:0006629

GO:0007165

GO:0007298

GO:0008081

GO:0009395

GO:0009653

GO:0010634

GO:0016042

GO:0016787

GO:0030307

GO:0032587

GO:0032868

GO:0035556

GO:0042059

GO:0042690

GO:0045596

GO:0045677

GO:0045873

GO:0046488

GO:0048015

GO:0048468

GO:0048856

GO:0048870

GO:0051209

GO:0055085

GO:0070373

Participates

as a component of

as an input of

Phospholipase C-gamma1 binds to the activated EGF receptor (Drosophila melanogaster)

Other forms of this molecule

phospho-sl [cytosol]

phospho-sl [plasma membrane]

phospho-sl [cytosol]

sl [cytosol]

phospho-sl [plasma membrane]

sl [plasma membrane]

phospho-sl [plasma membrane]

sl [plasma membrane]

phospho-sl [plasma membrane]

Inferred From

PLC gamma1,2 [cytosol] (Homo sapiens)

PLCG1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_476726.2

FlyBase

FBgn0003416

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