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phospho-Dmel\CG15529 [cytosol]
Stable Identifier
R-DME-202175
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
p-Y113,128,145-LCP2, Q9VAA1
Locations in the PathwayBrowser
Expand all
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
GPVI-mediated activation cascade (Drosophila melanogaster)
SLP-76 stimulates PLC gamma 2 (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Syk activation leads to SLP-76 activation (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
p-SLP-76 binds VAV (Drosophila melanogaster)
p-SLP-76:VAV [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
TCR signaling (Drosophila melanogaster)
Generation of second messenger molecules (Drosophila melanogaster)
NCK binds PAK (Drosophila melanogaster)
p-SLP-76:NCK1 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
p-SLP-76:NCK:PAK [cytosol] (Drosophila melanogaster)
p-SLP-76:NCK1 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Phosphorylation of PLC-gamma1 (Drosophila melanogaster)
ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Drosophila melanogaster)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Drosophila melanogaster)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Drosophila melanogaster)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
p-SLP-76 binds NCK (Drosophila melanogaster)
p-SLP-76:NCK1 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
DAP12 interactions (Drosophila melanogaster)
DAP12 signaling (Drosophila melanogaster)
Activation of RAC1 by VAV2/3 (Drosophila melanogaster)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Recruitment of VAV and BTK to p-SLP-76 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Release of p-PLCG1 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Autophosphorylation of BTK/ITK (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
FCERI mediated MAPK activation (Drosophila melanogaster)
Activation of RAC1 by VAV (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Autophosphorylation of PAK (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Phosphorylation and activation of VAV (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Recruitment of PAK to the membrane by binding active RAC1 (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
Recruitment of VAV to p-SLP-76 (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VAA1
Gene Names
Dmel\CG15529
Reference Genes
BioGPS Gene:43584 Dmel\CG15529
ENSEMBL:FBgn0039748
FlyBase:FBgn0039748
KEGG:dme:Dmel_CG15529 Dmel\CG15529
Monarch:43584 Dmel\CG15529
NCBI Gene:43584 Dmel\CG15529
UCSC:Q9VAA1 Dmel\CG15529
Reference Transcript
RefSeq:NM_001316558.1 Dmel\CG15529
RefSeq:NM_143516.4 Dmel\CG15529
Other Identifiers
150873_at
1633245_at
43584
GO:0005829
GO:0007169
GO:0035556
GO:0035591
GO:0060090
Participates
as an input of
p-SLP-76 binds VAV (Drosophila melanogaster)
p-SLP-76 binds NCK (Drosophila melanogaster)
as a component of
p-SLP-76:VAV [cytosol] (Drosophila melanogaster)
p-SLP-76:NCK1 [cytosol] (Drosophila melanogaster)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Drosophila melanogaster)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Drosophila melanogaster)
as an output of
Syk activation leads to SLP-76 activation (Drosophila melanogaster)
This entity regulates
Positively
SLP-76 stimulates PLC gamma 2
(Drosophila melanogaster)
Other forms of this molecule
Dmel\CG15529 [cytosol]
Inferred From
p-Y113,128,145-LCP2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 113 (in Homo sapiens)
Coordinate
113
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 128 (in Homo sapiens)
Coordinate
128
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 145 (in Homo sapiens)
Coordinate
145
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001303487.1
,
NP_651773.1
ENSEMBL
FBtr0347342
,
FBpp0312535
,
FBpp0084933
,
FBtr0085567
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:C0PV55 C0PV55
0.488
2
UniProt:Q8INN3 Q8INN3
0.488
2
UniProt:Q86BM2 Q86BM2
0.488
2
UniProt:Q9VFE6 RRP15
0.488
2
UniProt:Q9VMV9 Q9VMV9
0.488
2
UniProt:Q9VLU5
1
WWOX [cytosol]
(R-DME-1253335)
0.488
2
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