Reactome | sw [cytosol]

sw [cytosol]

Stable Identifier

R-DME-201578-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

DYNC1I1, Q24246

Locations in the PathwayBrowser

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Autophagy (Drosophila melanogaster)

- Macroautophagy (Drosophila melanogaster)
  - Selective autophagy (Drosophila melanogaster)
    - Aggrephagy (Drosophila melanogaster)
      - PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Drosophila melanogaster)
        
        Dynein complex [cytosol] (Drosophila melanogaster)
        
        DICs [cytosol] (Drosophila melanogaster)
        
        Homologues of DYNC1I1 [cytosol] (Drosophila melanogaster)
        
        sw [cytosol] (Drosophila melanogaster)
        
        PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Drosophila melanogaster)
        
        Dynein complex [cytosol] (Drosophila melanogaster)
        
        DICs [cytosol] (Drosophila melanogaster)
        
        Homologues of DYNC1I1 [cytosol] (Drosophila melanogaster)
        
        sw [cytosol] (Drosophila melanogaster)

Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Drosophila melanogaster)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Drosophila melanogaster)
      - Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynein complex [cytosol] (Drosophila melanogaster)
        
        DICs [cytosol] (Drosophila melanogaster)
        
        Homologues of DYNC1I1 [cytosol] (Drosophila melanogaster)
        
        sw [cytosol] (Drosophila melanogaster)

Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - Asparagine N-linked glycosylation (Drosophila melanogaster)
    - Transport to the Golgi and subsequent modification (Drosophila melanogaster)
      - ER to Golgi Anterograde Transport (Drosophila melanogaster)
        
        COPI-mediated anterograde transport (Drosophila melanogaster)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynein complex [cytosol] (Drosophila melanogaster)
        
        DICs [cytosol] (Drosophila melanogaster)
        
        Homologues of DYNC1I1 [cytosol] (Drosophila melanogaster)
        
        sw [cytosol] (Drosophila melanogaster)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynein complex [cytosol] (Drosophila melanogaster)
        
        DICs [cytosol] (Drosophila melanogaster)
        
        Homologues of DYNC1I1 [cytosol] (Drosophila melanogaster)
        
        sw [cytosol] (Drosophila melanogaster)

Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - ER to Golgi Anterograde Transport (Drosophila melanogaster)
    - COPI-mediated anterograde transport (Drosophila melanogaster)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynein complex [cytosol] (Drosophila melanogaster)
        
        DICs [cytosol] (Drosophila melanogaster)
        
        Homologues of DYNC1I1 [cytosol] (Drosophila melanogaster)
        
        sw [cytosol] (Drosophila melanogaster)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynein complex [cytosol] (Drosophila melanogaster)
        
        DICs [cytosol] (Drosophila melanogaster)
        
        Homologues of DYNC1I1 [cytosol] (Drosophila melanogaster)
        
        sw [cytosol] (Drosophila melanogaster)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Drosophila melanogaster)
    - Golgi-to-ER retrograde transport (Drosophila melanogaster)
      - COPI-independent Golgi-to-ER retrograde traffic (Drosophila melanogaster)
        
        Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynein complex [cytosol] (Drosophila melanogaster)
        
        DICs [cytosol] (Drosophila melanogaster)
        
        Homologues of DYNC1I1 [cytosol] (Drosophila melanogaster)
        
        sw [cytosol] (Drosophila melanogaster)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynein complex [cytosol] (Drosophila melanogaster)
        
        DICs [cytosol] (Drosophila melanogaster)
        
        Homologues of DYNC1I1 [cytosol] (Drosophila melanogaster)
        
        sw [cytosol] (Drosophila melanogaster)
        
        RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynein complex [cytosol] (Drosophila melanogaster)
        
        DICs [cytosol] (Drosophila melanogaster)
        
        Homologues of DYNC1I1 [cytosol] (Drosophila melanogaster)
        
        sw [cytosol] (Drosophila melanogaster)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Drosophila melanogaster)
        
        Dynein:Dynactin:microtubule [cytosol] (Drosophila melanogaster)
        
        Dynein complex [cytosol] (Drosophila melanogaster)
        
        DICs [cytosol] (Drosophila melanogaster)
        
        Homologues of DYNC1I1 [cytosol] (Drosophila melanogaster)
        
        sw [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q24246

Gene Names

Reference Genes

BioGPS Gene:44160 SW

CTD Gene:44160 SW

ENSEMBL:FBgn0003654

FlyBase:FBgn0003654

KEGG:dme:Dmel_CG18000 SW

Monarch:44160 SW

NCBI Gene:44160 SW

UCSC:Q24246 SW

Reference Transcript

Participates

as a member of

Homologues of DYNC1I1 [cytosol] (Drosophila melanogaster)

Other forms of this molecule

sw [cytosol]

Inferred From

DYNC1I1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_477075.2, NP_477074.1, NP_477073.1, NP_477076.1, NP_996522.1, NP_996521.1, NP_477069.1, NP_477077.1, NP_477078.1, NP_001285486.1, NP_477079.1, NP_477070.1, NP_477071.1, NP_477072.1

ENSEMBL

FBtr0089406, FBpp0088428, FBgn0003654

FlyBase

FBgn0003654

PRO

Q24246

PDB

2P2T, 3FM7, 3L9K

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