Reactome | CrebB [nucleoplasm]

CrebB [nucleoplasm]

Stable Identifier

R-DME-199900

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

ATF1, Q9VWW0

Locations in the PathwayBrowser

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Immune System (Drosophila melanogaster)

- Cytokine Signaling in Immune system (Drosophila melanogaster)
  - Signaling by Interleukins (Drosophila melanogaster)
    - Interleukin-17 signaling (Drosophila melanogaster)
      - MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        CREB phosphorylation (Drosophila melanogaster)
        
        MSK1 activates ATF1 (Drosophila melanogaster)
        
        CrebB [nucleoplasm] (Drosophila melanogaster)
- Innate Immune System (Drosophila melanogaster)
  - Toll-like Receptor Cascades (Drosophila melanogaster)
    - Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
      - MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        CREB phosphorylation (Drosophila melanogaster)
        
        MSK1 activates ATF1 (Drosophila melanogaster)
        
        CrebB [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
      - Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        CREB phosphorylation (Drosophila melanogaster)
        
        MSK1 activates ATF1 (Drosophila melanogaster)
        
        CrebB [nucleoplasm] (Drosophila melanogaster)
      - Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        CREB phosphorylation (Drosophila melanogaster)
        
        MSK1 activates ATF1 (Drosophila melanogaster)
        
        CrebB [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
      - MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        CREB phosphorylation (Drosophila melanogaster)
        
        MSK1 activates ATF1 (Drosophila melanogaster)
        
        CrebB [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
      - MyD88-independent TLR4 cascade (Drosophila melanogaster)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        CREB phosphorylation (Drosophila melanogaster)
        
        MSK1 activates ATF1 (Drosophila melanogaster)
        
        CrebB [nucleoplasm] (Drosophila melanogaster)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        CREB phosphorylation (Drosophila melanogaster)
        
        MSK1 activates ATF1 (Drosophila melanogaster)
        
        CrebB [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
      - MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        CREB phosphorylation (Drosophila melanogaster)
        
        MSK1 activates ATF1 (Drosophila melanogaster)
        
        CrebB [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
      - MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        CREB phosphorylation (Drosophila melanogaster)
        
        MSK1 activates ATF1 (Drosophila melanogaster)
        
        CrebB [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
      - MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        CREB phosphorylation (Drosophila melanogaster)
        
        MSK1 activates ATF1 (Drosophila melanogaster)
        
        CrebB [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
  - Signaling by NTRKs (Drosophila melanogaster)
    - Signaling by NTRK1 (TRKA) (Drosophila melanogaster)
      - Nuclear Events (kinase and transcription factor activation) (Drosophila melanogaster)
        
        CREB phosphorylation (Drosophila melanogaster)
        
        MSK1 activates ATF1 (Drosophila melanogaster)
        
        CrebB [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VWW0

Gene Names

CrebB

Reference Genes

BioGPS Gene:32817 CrebB

CTD Gene:32817 CrebB

ENSEMBL:FBgn0265784

FlyBase:FBgn0265784

KEGG:dme:Dmel_CG6103 CrebB

Monarch:32817 CrebB

NCBI Gene:32817 CrebB

UCSC:Q9VWW0 CrebB

Reference Transcript

Other Identifiers

143761_at

1631345_at

1635570_a_at

32817

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0006355

Participates

as an input of

MSK1 activates ATF1 (Drosophila melanogaster)

Other forms of this molecule

phospho-CrebB [nucleoplasm]

CrebB [nucleoplasm]

phospho-CrebB [nucleoplasm]

Inferred From

ATF1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001097018.1, NP_996506.2, NP_996504.1, NP_001097017.1, NP_001097016.2, NP_001334685.1, NP_001259677.1, NP_001259678.1

ENSEMBL

FBpp0402805, FBtr0446106, FBgn0265784

FlyBase

FBgn0265784

PRO

Q9VWW0

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