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Vav [cytosol]
Stable Identifier
R-DME-195066
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
VAV1, Q9NHV9
Locations in the PathwayBrowser
Expand all
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
GPVI-mediated activation cascade (Drosophila melanogaster)
VAV1 is a GEF for Rho/Rac family GTPases (Drosophila melanogaster)
PIP3:VAV1,2,3 [plasma membrane] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
VAV family:PIP2 [plasma membrane] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
p-SLP-76 binds VAV (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
p-SLP-76:VAV [cytosol] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Cytokine Signaling in Immune system (Drosophila melanogaster)
Signaling by Interleukins (Drosophila melanogaster)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Drosophila melanogaster)
IL3 stimulation induces Vav binding to Tec kinase (Drosophila melanogaster)
TEC:VAV1 [cytosol] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
Regulation of signaling by CBL (Drosophila melanogaster)
CBL binds VAV (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
FCERI mediated Ca+2 mobilization (Drosophila melanogaster)
Autophosphorylation of BTK/ITK (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
FCERI mediated MAPK activation (Drosophila melanogaster)
Phosphorylation and activation of VAV (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
Recruitment of VAV to p-SLP-76 (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Death Receptor Signaling (Drosophila melanogaster)
p75 NTR receptor-mediated signalling (Drosophila melanogaster)
Cell death signalling via NRAGE, NRIF and NADE (Drosophila melanogaster)
NRAGE signals death through JNK (Drosophila melanogaster)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Drosophila melanogaster)
GEFs [cytosol] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
Signaling by Erythropoietin (Drosophila melanogaster)
Erythropoietin activates RAS (Drosophila melanogaster)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Drosophila melanogaster)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Drosophila melanogaster)
GRB2-1:VAV1 [cytosol] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
GRB2-1:VAV1 [cytosol] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (12/13) signalling events (Drosophila melanogaster)
GEFs activate RhoA,B,C (Drosophila melanogaster)
GEFs [cytosol] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VAV exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase cycle (Drosophila melanogaster)
RAC1 GTPase cycle (Drosophila melanogaster)
RAC1 GEFs activate RAC1 (Drosophila melanogaster)
RAC1 GEFs [cytosol] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
RAC2 GTPase cycle (Drosophila melanogaster)
RAC2 GEFs activate RAC2 (Drosophila melanogaster)
RAC2 GEFs [cytosol] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
RHOA GTPase cycle (Drosophila melanogaster)
RHOA GEFs activate RHOA (Drosophila melanogaster)
RHOA GEFs [cytosol] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
RHOG GTPase cycle (Drosophila melanogaster)
RHOG GEFs activate RHOG (Drosophila melanogaster)
RHOG GEFs [cytosol] (Drosophila melanogaster)
Vav [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9NHV9
Gene Names
Vav
Reference Genes
BioGPS Gene:32920 Vav
ENSEMBL:FBgn0040068
FlyBase:FBgn0040068
KEGG:dme:Dmel_CG7893 Vav
Monarch:32920 Vav
NCBI Gene:32920 Vav
UCSC:Q9NHV9 Vav
Reference Transcript
RefSeq:NM_167642.3 Vav
RefSeq:NM_133144.4 Vav
Other Identifiers
142127_at
151471_at
1635592_at
1636614_a_at
32920
GO:0001745
GO:0002009
GO:0002376
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0007010
GO:0007173
GO:0007298
GO:0007391
GO:0007409
GO:0007411
GO:0007417
GO:0007424
GO:0007520
GO:0009653
GO:0016043
GO:0016477
GO:0030036
GO:0031532
GO:0032956
GO:0035011
GO:0042059
GO:0043087
GO:0046872
GO:0048010
GO:0048468
GO:0048513
GO:0048856
GO:0048870
GO:0070374
GO:0072499
GO:0090630
GO:0098542
GO:0098772
GO:1903391
GO:2000251
Participates
as a component of
GRB2-1:VAV1 [cytosol] (Drosophila melanogaster)
VAV family:PIP2 [plasma membrane] (Drosophila melanogaster)
p-SLP-76:VAV [cytosol] (Drosophila melanogaster)
TEC:VAV1 [cytosol] (Drosophila melanogaster)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Drosophila melanogaster)
PIP3:VAV1,2,3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Drosophila melanogaster)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Drosophila melanogaster)
as a member of
RHOA GEFs [cytosol] (Drosophila melanogaster)
RAC2 GEFs [cytosol] (Drosophila melanogaster)
RAC1 GEFs [cytosol] (Drosophila melanogaster)
RHOG GEFs [cytosol] (Drosophila melanogaster)
GEFs [cytosol] (Drosophila melanogaster)
as an input of
p-SLP-76 binds VAV (Drosophila melanogaster)
IL3 stimulation induces Vav binding to Tec kinase (Drosophila melanogaster)
CBL binds VAV (Drosophila melanogaster)
Recruitment of VAV to p-SLP-76 (Drosophila melanogaster)
Other forms of this molecule
phospho-Vav [plasma membrane]
Vav [cytosol]
Vav [cytosol]
phospho-Vav [cytosol]
phospho-Vav [cytosol]
phospho-Vav [cytosol]
Vav [plasma membrane]
Inferred From
VAV family [cytosol]
(Homo sapiens)
VAV1,2,3 [cytosol]
(Homo sapiens)
VAV1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_573372.1
,
NP_728235.1
ENSEMBL
FBtr0074677
,
FBtr0074678
,
FBpp0074448
,
FBpp0074449
PRO
Q9NHV9
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