Reactome | btd [nucleoplasm]

btd [nucleoplasm]

Stable Identifier

R-DME-1592223

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

SP1, Q24266

Locations in the PathwayBrowser

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Cell-Cell communication (Drosophila melanogaster)

- Cell junction organization (Drosophila melanogaster)
  - Cell-cell junction organization (Drosophila melanogaster)
    - Adherens junctions interactions (Drosophila melanogaster)
      - Regulation of Homotypic Cell-Cell Adhesion (Drosophila melanogaster)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Drosophila melanogaster)
        
        Regulation of CDH11 Expression and Function (Drosophila melanogaster)
        
        Regulation of CDH11 gene transcription (Drosophila melanogaster)
        
        ZEB2 binds SP1 (Drosophila melanogaster)
        
        ZEB2:SP1 [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Drosophila melanogaster)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Drosophila melanogaster)
        
        SMAD2/3:SMAD4 heterotrimer binds SP1 (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)
        
        p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)
  - RNA polymerase II transcribes snRNA genes (Drosophila melanogaster)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)
    - Integrator complex processes the 3' end of snRNA (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Drosophila melanogaster)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Drosophila melanogaster)
        
        btd [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q24266

Gene Names

btd

Reference Genes

BioGPS Gene:31912 btd

ENSEMBL:FBgn0000233

FlyBase:FBgn0000233

KEGG:dme:Dmel_CG12653 btd

Monarch:31912 btd

NCBI Gene:31912 btd

UCSC:Q24266 btd

Reference Transcript

RefSeq:NM_078545.3 btd

Other Identifiers

143091_at

1633396_at

31912

GO:0000122

GO:0000978

GO:0000981

GO:0003677

GO:0003700

GO:0005634

GO:0006355

GO:0006357

GO:0007376

GO:0007480

GO:0008270

GO:0017025

GO:0035288

GO:0035289

GO:0043565

GO:0045664

GO:0045944

GO:0046872

GO:1902692

Participates

as an input of

as a component of

Other forms of this molecule

btd [nucleoplasm]

Inferred From

SP1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_511100.1

ENSEMBL

FBtr0071379, FBpp0071314, FBgn0000233

FlyBase

FBgn0000233

PRO

Q24266

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q29QK1 Q29QK1			0.488	2
UniProt:Q05856	3	SmB [nucleoplasm] (R-DME-192213) SmB [nucleoplasm] (R-DME-71896) SmB [cytosol] (R-DME-191798)	0.488	2
UniProt:Q9W0A2 Q9W0A2			0.488	2

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