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phospho-p-T161-CDK1 [cytosol]
Stable Identifier
R-DME-157415
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
P23572
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
M Phase (Drosophila melanogaster)
Mitotic Metaphase and Anaphase (Drosophila melanogaster)
Mitotic Anaphase (Drosophila melanogaster)
Nuclear Envelope (NE) Reassembly (Drosophila melanogaster)
Initiation of Nuclear Envelope (NE) Reformation (Drosophila melanogaster)
CDK1 phosphorylates LBR (Drosophila melanogaster)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Mitotic Prometaphase (Drosophila melanogaster)
Resolution of Sister Chromatid Cohesion (Drosophila melanogaster)
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Drosophila melanogaster)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Mitotic Prophase (Drosophila melanogaster)
Nuclear Envelope Breakdown (Drosophila melanogaster)
Nuclear Pore Complex (NPC) Disassembly (Drosophila melanogaster)
CDK1 phosphorylates NUP98 (Drosophila melanogaster)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
Cyclin A/B1/B2 associated events during G2/M transition (Drosophila melanogaster)
CCNA:CDK1 complex translocates to the cytosol (Drosophila melanogaster)
p-S-CCNA:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
p-S154-CCNA2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
p-S183-CCNA1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNA:CDK1 phosphorylates BORA (Drosophila melanogaster)
p-S-CCNA:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
p-S154-CCNA2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
p-S183-CCNA1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Drosophila melanogaster)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Phosphorylation of Cyclin B1 in the CRS domain (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CRS kinase [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes (Drosophila melanogaster)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Drosophila melanogaster)
cytoplasmic Cyclin B1:Cdc2 complexes [cytosol] (Drosophila melanogaster)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Regulation of PLK1 Activity at G2/M Transition (Drosophila melanogaster)
CCNB:CDK1 phosphorylates BORA (Drosophila melanogaster)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Regulation of mitotic cell cycle (Drosophila melanogaster)
APC/C-mediated degradation of cell cycle proteins (Drosophila melanogaster)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of Cyclin B (Drosophila melanogaster)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Degradation of multiubiquitinated Cyclin B (Drosophila melanogaster)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Drosophila melanogaster)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Drosophila melanogaster)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Drosophila melanogaster)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Drosophila melanogaster)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Drosophila melanogaster)
Association of Cyclin A with the APC/C (Drosophila melanogaster)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Drosophila melanogaster)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Drosophila melanogaster)
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF-independent MAPK1/3 activation (Drosophila melanogaster)
MAPK3 (ERK1) activation (Drosophila melanogaster)
Inactivation of MAP2K1 by CDK1 (Drosophila melanogaster)
phospho-p-T161-CDK1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P23572
Reference Genes
BioGPS Gene:34411
ENSEMBL:FBgn0004106
FlyBase:FBgn0004106
KEGG:dme:Dmel_CG5363
Monarch:34411
NCBI Gene:34411
UCSC:P23572
Reference Transcript
RefSeq:NM_057449.4
Other Identifiers
154844_at
1631861_at
34411
GO:0000082
GO:0000086
GO:0000166
GO:0001700
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005634
GO:0006355
GO:0006357
GO:0006468
GO:0007095
GO:0007140
GO:0007284
GO:0008353
GO:0016301
GO:0016740
GO:0022414
GO:0030174
GO:0030707
GO:0032880
GO:0044818
GO:0045169
GO:0048142
GO:0048856
GO:0051301
GO:0055059
GO:0106310
GO:0140013
GO:0140096
GO:1901990
Participates
as an output of
Degradation of multiubiquitinated Cyclin B (Drosophila melanogaster)
Degradation multiubiquitinated Cyclin A (Drosophila melanogaster)
as a component of
Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] (Drosophila melanogaster)
p-S154-CCNA2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
p-S183-CCNA1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB2:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
CCNB1:p-T161-CDK1 [cytosol] (Drosophila melanogaster)
phospho-cyclin B1(CRS):phosph-Cdc2(Thr 161) [cytosol] (Drosophila melanogaster)
Other forms of this molecule
phospho-p-Y4-CDK1 [cytosol]
phospho-p-T14,T161-CDK1 [nucleoplasm]
phospho-p-T14-CDK1 [nucleoplasm]
phospho-p-T14-CDK1 [cytosol]
CDK1 [cytosol]
phospho-p-T14,Y15,T161-CDK1 [cytosol]
phospho-p-T14,Y15,T161-CDK1 [nucleoplasm]
phospho-p-T161-CDK1 [nucleoplasm]
Inferred From
p-T161-CDK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 161 (in Homo sapiens)
Coordinate
161
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_476797.1
ENSEMBL
FBtr0080051
,
FBpp0079641
,
FBgn0004106
FlyBase
FBgn0004106
PRO
P23572
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54733
4
CycE [cytosol]
(R-DME-157452)
CycE [nucleoplasm]
(R-DME-68367)
CycE [nucleoplasm]
(R-DME-68363)
CycE [cytosol]
(R-DME-157443)
0.785
6
UniProt:Q9VHN1 Q9VHN1
0.712
5
UniProt:P14785
10
CycA [nucleoplasm]
(R-DME-6783099)
CycA [nucleoplasm]
(R-DME-6783068)
CycA [cytosol]
(R-DME-157446)
CycA [cytosol]
(R-DME-157444)
CycA [nucleoplasm]
(R-DME-68905)
CycA [nucleoplasm]
(R-DME-68891)
phospho-CycA [cytosol]
(R-DME-9929551)
phospho-CycA [cytosol]
(R-DME-9929540)
phospho-CycA [nucleoplasm]
(R-DME-9929512)
phospho-CycA [nucleoplasm]
(R-DME-9929513)
0.657
3
UniProt:Q9I7I0 CCNB3
0.623
3
UniProt:Q03019
20
twe [nucleoplasm]
(R-DME-143487-2)
phospho-twe [nucleoplasm]
(R-DME-156668-2)
twe [cytosol]
(R-DME-157879-2)
phospho-twe [cytosol]
(R-DME-8981697-2)
twe [nucleoplasm]
(R-DME-69741-2)
twe [cytosol]
(R-DME-157410-2)
phospho-twe [nucleoplasm]
(R-DME-156496-2)
phospho-twe [cytosol]
(R-DME-75003-2)
phospho-twe [nucleoplasm]
(R-DME-9944031-2)
phospho-twe [nucleoplasm]
(R-DME-9944025-2)
phospho-twe [nucleoplasm]
(R-DME-9944029-2)
phospho-twe [nucleoplasm]
(R-DME-9944023-2)
phospho-twe [nucleoplasm]
(R-DME-9944028-2)
phospho-twe [nucleoplasm]
(R-DME-9944027-2)
phospho-twe [nucleoplasm]
(R-DME-9944026-2)
phospho-twe [nucleoplasm]
(R-DME-9944024-2)
phospho-twe [nucleoplasm]
(R-DME-9944032-2)
phospho-twe [nucleoplasm]
(R-DME-9943707-2)
phospho-twe [nucleoplasm]
(R-DME-9943704-2)
phospho-twe [nucleoplasm]
(R-DME-9943711-2)
0.621
4
UniProt:P25008
1
CycC [nucleoplasm]
(R-DME-212418)
0.621
4
UniProt:Q961D1
1
CycK [nucleoplasm]
(R-DME-6796619)
0.621
4
UniProt:Q24152
1
Cks30A [nucleoplasm]
(R-DME-187533)
0.547
2
UniProt:P20439
5
CycB [cytosol]
(R-DME-68897)
CycB [cytosol]
(R-DME-157451)
phospho-CycB [nucleoplasm]
(R-DME-170049)
phospho-CycB [cytosol]
(R-DME-170058)
CycB [nucleoplasm]
(R-DME-68901)
0.527
2
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