Reactome | rsmA [plasma membrane]

rsmA [plasma membrane]

Stable Identifier

R-DDI-9647815-7

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

plasma membrane

Synonyms

S-Farn-Me KRAS4B, Q54QY0

Locations in the PathwayBrowser

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Immune System (Dictyostelium discoideum)

- Adaptive Immune System (Dictyostelium discoideum)
  - Signaling by the B Cell Receptor (BCR) (Dictyostelium discoideum)
    - Downstream signaling events of B Cell Receptor (BCR) (Dictyostelium discoideum)
      - Activation of RAS in B cells (Dictyostelium discoideum)
        
        p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Dictyostelium discoideum)
        
        p21 RAS:GDP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
- Innate Immune System (Dictyostelium discoideum)
  - C-type lectin receptors (CLRs) (Dictyostelium discoideum)
    - CD209 (DC-SIGN) signaling (Dictyostelium discoideum)
      - PAK phosphorylates p21 RAF1 on S338 (Dictyostelium discoideum)
        
        p21 RAS:GTP:RAF1 [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:p-S338-RAF1 [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
      - RAF1 binds p21 RAS:GTP (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:RAF1 [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)

Signal Transduction (Dictyostelium discoideum)

- MAPK family signaling cascades (Dictyostelium discoideum)
  - MAPK1/MAPK3 signaling (Dictyostelium discoideum)
    - RAF/MAP kinase cascade (Dictyostelium discoideum)
      - Intrinsic nucleotide exchange on RAS (Dictyostelium discoideum)
        
        p21 RAS:GDP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
      - MAP2K and MAPK activation (Dictyostelium discoideum)
        
        Dissociation of RAS:RAF complex (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        RAF phosphorylates MAP2K dimer (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
      - Negative regulation of MAPK pathway (Dictyostelium discoideum)
        
        BRAP autoubiquitinates (Dictyostelium discoideum)
        
        p21 RAS:GTP:BRAP [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:ub-BRAP [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        BRAP binds RAS:GTP (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:BRAP [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        PEBP1 binds activated RAF1 (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        PP2A dephosphorylates RAF1 (Dictyostelium discoideum)
        
        p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        PP5 dephosphorylates RAF1 S338 (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
      - RAF activation (Dictyostelium discoideum)
        
        Raf dimer inhibitors bind RAF heterodimers (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
      - RAS GEFs promote RAS nucleotide exchange (Dictyostelium discoideum)
        
        p21 RAS:GDP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
      - RAS intrinsic GTPase activity hydrolyzes GTP to GDP (Dictyostelium discoideum)
        
        p21 RAS:GDP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
      - RAS processing (Dictyostelium discoideum)
        
        KRAS4B is phosphorylated on serine 181 (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        Mature S-Farn-Me KRAS4B translocates to plasma membrane (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS binds GDP (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GDP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
      - Regulation of RAS by GAPs (Dictyostelium discoideum)
        
        RAS GAPs bind RAS:GTP (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:RAS GAPs [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        RAS GAPs stimulate RAS GTPase activity (Dictyostelium discoideum)
        
        p21 RAS:GDP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:RAS GAPs [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
- Signaling by Non-Receptor Tyrosine Kinases (Dictyostelium discoideum)
  - Signaling by PTK6 (Dictyostelium discoideum)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Dictyostelium discoideum)
      - RASA1 binds RAS:GTP (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:RASA1 [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
      - RASA1 stimulates RAS GTPase activity (Dictyostelium discoideum)
        
        p21 RAS:GDP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:RASA1 [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
- Signaling by Nuclear Receptors (Dictyostelium discoideum)
  - ESR-mediated signaling (Dictyostelium discoideum)
    - Extra-nuclear estrogen signaling (Dictyostelium discoideum)
      - Estrogen-stimulated signaling through PRKCZ (Dictyostelium discoideum)
        
        ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Dictyostelium discoideum)
        
        PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        PRKCZ recruits RAS in response to estrogen stimulation (Dictyostelium discoideum)
        
        PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GDP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GDP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Dictyostelium discoideum)
        
        PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GDP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
- Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
  - Signaling by NTRKs (Dictyostelium discoideum)
    - Signaling by NTRK1 (TRKA) (Dictyostelium discoideum)
      - Signalling to ERKs (Dictyostelium discoideum)
        
        Signalling to RAS (Dictyostelium discoideum)
        
        p38MAPK events (Dictyostelium discoideum)
        
        Ral-GDS binds to Ras-GTP (Dictyostelium discoideum)
        
        Ras-GTP:RalGDS complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
  - Signaling by VEGF (Dictyostelium discoideum)
    - VEGFA-VEGFR2 Pathway (Dictyostelium discoideum)
      - VEGFR2 mediated cell proliferation (Dictyostelium discoideum)
        
        p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Dictyostelium discoideum)
        
        RASA1:p21 RAS:GTP:SPG [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP [plasma membrane] (Dictyostelium discoideum)
        
        mature p21 RAS [plasma membrane] (Dictyostelium discoideum)
        
        Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)
        
        rsmA [plasma membrane] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54QY0

Gene Names

rsmA

Reference Genes

BioGPS Gene:8624134 rsmA

dictyBase:DDB_G0283547

ENSEMBL:DDB_G0283547

KEGG:ddi:DDB_G0283547 rsmA

Monarch:8624134 rsmA

NCBI Gene:8624134 rsmA

UCSC:Q54QY0 rsmA

Reference Transcript

RefSeq:XM_633912.1 rsmA

Participates

as a member of

Homologues of S-Farn-Me KRAS4B [plasma membrane] (Dictyostelium discoideum)

Other forms of this molecule

phospho-rsmA [plasma membrane]

rsmA [tertiary granule membrane]

rsmA [plasma membrane]

phospho-rsmA [mitochondrial outer membrane]

phospho-rsmA [plasma membrane]

rsmA [Golgi membrane]

rsmA [cytosol]

rsmA [endoplasmic reticulum membrane]

rsmA [plasma membrane]

Inferred From

S-Farn-Me KRAS4B [plasma membrane] (Homo sapiens)

Modified Residues

Name

S-farnesyl-L-cysteine methyl ester at 185 (in Homo sapiens)

Coordinate

185

PsiMod Name

S-farnesyl-L-cysteine methyl ester

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester.

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