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p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
Stable Identifier
R-DDI-5672705
Type
Complex
Species
Dictyostelium discoideum
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Dictyostelium discoideum)
MAPK family signaling cascades (Dictyostelium discoideum)
MAPK1/MAPK3 signaling (Dictyostelium discoideum)
RAF/MAP kinase cascade (Dictyostelium discoideum)
MAP2K and MAPK activation (Dictyostelium discoideum)
Dissociation of RAS:RAF complex (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
Dual mechanism MAPK inhibitors bind MAPKs (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Dictyostelium discoideum)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Dictyostelium discoideum)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
RAF phosphorylates MAP2K dimer (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
Negative regulation of MAPK pathway (Dictyostelium discoideum)
Negative feedback regulation of MAPK pathway (Dictyostelium discoideum)
Activated MAPKs phosphorylate MAP2K1 (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by NTRKs (Dictyostelium discoideum)
Signaling by NTRK1 (TRKA) (Dictyostelium discoideum)
Signalling to ERKs (Dictyostelium discoideum)
Prolonged ERK activation events (Dictyostelium discoideum)
Frs2-mediated activation (Dictyostelium discoideum)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Dictyostelium discoideum)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Dictyostelium discoideum)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Dictyostelium discoideum)
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Dictyostelium discoideum)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
phospho-p-S218,S222-MAP2K1 [cytosol]
(Dictyostelium discoideum)
phospho-p-S222,S226-MAP2K2 [cytosol]
(Dictyostelium discoideum)
Participates
as an input of
Activated MAPKs phosphorylate MAP2K1 (Dictyostelium discoideum)
as a member of
p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)
Inferred From
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
(Homo sapiens)
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