Reactome | Homologues of p-S446,S729-BRAF [cytosol]

Homologues of p-S446,S729-BRAF [cytosol]

Stable Identifier

R-DDI-5672673-4

Type

Set [DefinedSet]

Species

Dictyostelium discoideum

Compartment

cytosol

Locations in the PathwayBrowser

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Signal Transduction (Dictyostelium discoideum)

- MAPK family signaling cascades (Dictyostelium discoideum)
  - MAPK1/MAPK3 signaling (Dictyostelium discoideum)
    - RAF/MAP kinase cascade (Dictyostelium discoideum)
      - MAP2K and MAPK activation (Dictyostelium discoideum)
        
        Dissociation of RAS:RAF complex (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        RAF phosphorylates MAP2K dimer (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAF:YWHAB dimer [cytosol] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
      - Negative regulation of MAPK pathway (Dictyostelium discoideum)
        
        PEBP1 binds activated RAF1 (Dictyostelium discoideum)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        PP2A dephosphorylates RAF1 (Dictyostelium discoideum)
        
        p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        PP5 dephosphorylates RAF1 S338 (Dictyostelium discoideum)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
      - RAF activation (Dictyostelium discoideum)
        
        Raf dimer inhibitors bind RAF heterodimers (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAF:YWHAB dimer [cytosol] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Dictyostelium discoideum)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Dictyostelium discoideum)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Dictyostelium discoideum)
        
        'activator' RAF:YWHAB dimer [cytosol] (Dictyostelium discoideum)
        
        'activator' RAFs [cytosol] (Dictyostelium discoideum)
        
        Homologues of p-S446,S729-BRAF [cytosol] (Dictyostelium discoideum)

Participants

members

Participates

as a member of

Inferred From

p-S446,S729-BRAF [cytosol] (Homo sapiens)

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