Reactome | H2Av3 [nucleoplasm]

H2Av3 [nucleoplasm]

Stable Identifier

R-DDI-56151

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

nucleoplasm

Synonyms

H2AFX, Q54HV7

Locations in the PathwayBrowser

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Cell Cycle (Dictyostelium discoideum)

- Cell Cycle, Mitotic (Dictyostelium discoideum)
  - M Phase (Dictyostelium discoideum)
    - Mitotic Prophase (Dictyostelium discoideum)
      - Condensation of Prophase Chromosomes (Dictyostelium discoideum)
        
        Condensin II complex binds H4K20me1-containing nucleosomes (Dictyostelium discoideum)
        
        Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
        
        PHF8 demethylates histone H4K20me1 (Dictyostelium discoideum)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
        
        PLK1 binds phosphorylated condensin II complex (Dictyostelium discoideum)
        
        Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
        
        PLK1 hyperphosphorylates Condensin II complex (Dictyostelium discoideum)
        
        Hyperphosphorylated Condensin II:Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)

Cellular responses to stimuli (Dictyostelium discoideum)

- Cellular responses to stress (Dictyostelium discoideum)
  - Cellular Senescence (Dictyostelium discoideum)
    - Oxidative Stress Induced Senescence (Dictyostelium discoideum)
      - KDM6B demethylates H3K27me3 on p16INK4A promoter (Dictyostelium discoideum)
        
        CDKN2A Gene:H3K27Me3-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K27me3 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
        
        CDKN2A Gene:Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)

Chromatin organization (Dictyostelium discoideum)

- ATP-dependent chromatin remodelers (Dictyostelium discoideum)
  - CHD chromatin remodelers (Dictyostelium discoideum)
    - CHD1 and CHD2 subfamily (Dictyostelium discoideum)
      - CHD1 and CHD2 bind H3K4me3 nucleosomes (Dictyostelium discoideum)
        
        CHD1,CHD2:H3K4me3 chromatin [nucleoplasm] (Dictyostelium discoideum)
        
        chromatin with H3K4me3 nucleosomes [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
        
        chromatin with H3K4me3 nucleosomes [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
      - CHD1:H3K4me3 interacts with post-initiation transcription complexes (Dictyostelium discoideum)
        
        CHD1:H3K4 nucleosome:FACT complex:U2 snRNP complex:PAF1C complex [nucleoplasm] (Dictyostelium discoideum)
        
        CHD1:H3K4me3 chromatin [nucleoplasm] (Dictyostelium discoideum)
        
        chromatin with H3K4me3 nucleosomes [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
        
        CHD1:H3K4me3 chromatin [nucleoplasm] (Dictyostelium discoideum)
        
        chromatin with H3K4me3 nucleosomes [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
    - CHD6, CHD7, CHD8, CHD9 subfamily (Dictyostelium discoideum)
      - CHD6-9-dependent ATP hydrolysis (Dictyostelium discoideum)
        
        chromatin [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
- Chromatin modifying enzymes (Dictyostelium discoideum)
  - RMTs methylate histone arginines (Dictyostelium discoideum)
    - PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Dictyostelium discoideum)
      - Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)

DNA Replication (Dictyostelium discoideum)

- DNA Replication Pre-Initiation (Dictyostelium discoideum)
  - Assembly of the pre-replicative complex (Dictyostelium discoideum)
    - Assembly of the ORC complex at the origin of replication (Dictyostelium discoideum)
      - ORC1 binds to H4K20me2 (Dictyostelium discoideum)
        
        H4K20Me2-nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
        
        ORC1:H4K20Me2-nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        H4K20Me2-nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)

Gene expression (Transcription) (Dictyostelium discoideum)

- RNA Polymerase I Transcription (Dictyostelium discoideum)
  - RNA Polymerase I Promoter Clearance (Dictyostelium discoideum)
    - RNA Polymerase I Promoter Escape (Dictyostelium discoideum)
      - Elongation of pre-rRNA transcript (Dictyostelium discoideum)
        
        Chromatin (H3K9me2):CBX3 [nucleoplasm] (Dictyostelium discoideum)
        
        Chromatin (H3K9me2) [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K9me2 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)

Immune System (Dictyostelium discoideum)

- Adaptive Immune System (Dictyostelium discoideum)
  - Regulation of T cell activation by CD28 family (Dictyostelium discoideum)
    - Co-inhibition by PD-1 (Dictyostelium discoideum)
      - Regulation of PD-L1(CD274) expression (Dictyostelium discoideum)
        
        Regulation of PD-L1(CD274) transcription (Dictyostelium discoideum)
        
        Trimethylation of CD274 gene chromatin by MLL1/3 complex (Dictyostelium discoideum)
        
        CD274 gene chromatin:MLL1,MLL3 complex [nucleoplasm] (Dictyostelium discoideum)
        
        CD274 gene chromatin [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)
        
        MLL1,MLL3_complex:CD274 gene H3K4me3 chromatin [nucleoplasm] (Dictyostelium discoideum)
        
        CD274 gene H3K4me3 chromatin [nucleoplasm] (Dictyostelium discoideum)
        
        Nucleosome with H3K4me3 [nucleoplasm] (Dictyostelium discoideum)
        
        Histone H2A [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        H2Av3 [nucleoplasm] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54HV7

Gene Names

H2Av3

Reference Genes

BioGPS Gene:8627005 H2Av3

dictyBase:DDB_G0289197

ENSEMBL:DDB_G0289197

KEGG:ddi:DDB_G0289197 H2Av3

Monarch:8627005 H2Av3

NCBI Gene:8627005 H2Av3

UCSC:Q54HV7 H2Av3

Reference Transcript

RefSeq:XM_631240.1 H2Av3

Participates

as a member of

Homologues of H2AFX [nucleoplasm] (Dictyostelium discoideum)

Other forms of this molecule

H2Av3 [nucleoplasm]

phospho-H2Av3 [nucleoplasm]

H2Av3 [nucleoplasm]

Inferred From

H2AFX [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_636332.1

PRO

Q54HV7

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