Reactome | p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]

p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]

Stable Identifier

R-DDI-5357794

Type

Complex

Species

Dictyostelium discoideum

Compartment

cytosol

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

p-S-RIPK1:p-S199,227-RIPK3 oligomer [cytosol] (Dictyostelium discoideum)
p-T357,S358-MLKL oligomer [cytosol] (Dictyostelium discoideum)

Participates

as an input of

MLKL binds PIPs (Dictyostelium discoideum)

as a component of

p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer:PDCD6IP:SDCBP [cytosol] (Dictyostelium discoideum)
RIP1:RIP3:MLKL oligomer:PIPs [plasma membrane] (Dictyostelium discoideum)

This entity regulates

Positively

TRPA1 tetramer transports Ca2+ from extracellular region to cytosol (Dictyostelium discoideum)
TRPs transport extracellular Ca2+ to cytosol (Dictyostelium discoideum)

Inferred From

p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol] (Homo sapiens)

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