Reactome | act3 [cytosol]

act3 [cytosol]

Stable Identifier

R-DDI-201861-2

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

ACTB, P07829

Locations in the PathwayBrowser

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Hemostasis (Dictyostelium discoideum)

- Platelet activation, signaling and aggregation (Dictyostelium discoideum)
  - Response to elevated platelet cytosolic Ca2+ (Dictyostelium discoideum)
    - Platelet degranulation (Dictyostelium discoideum)
      - Release of platelet cytosolic components (Dictyostelium discoideum)
        
        Platelet releasate cytosolic proteins [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)

Immune System (Dictyostelium discoideum)

- Cytokine Signaling in Immune system (Dictyostelium discoideum)
  - Interferon Signaling (Dictyostelium discoideum)
    - Antimicrobial mechanism of IFN-stimulated genes (Dictyostelium discoideum)
      - GBP-mediated host defense (Dictyostelium discoideum)
        
        GBP1 binds actin (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        GBP1:G-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
- Innate Immune System (Dictyostelium discoideum)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Dictyostelium discoideum)
    - Regulation of actin dynamics for phagocytic cup formation (Dictyostelium discoideum)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
      - Branching and elongation of mother and daughter filaments (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Dictyostelium discoideum)
        
        Actin:ADP [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        Mother filament:branching complex:daughter filament [cytosol] (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
      - Detachment of WASP/WAVE (Dictyostelium discoideum)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Dictyostelium discoideum)
        
        Actin:ADP [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)

Signal Transduction (Dictyostelium discoideum)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Dictyostelium discoideum)
  - Signaling by Rho GTPases (Dictyostelium discoideum)
    - RHO GTPase Effectors (Dictyostelium discoideum)
      - RHO GTPases Activate WASPs and WAVEs (Dictyostelium discoideum)
        
        (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        Branching and elongation of mother and daughter filaments (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Dictyostelium discoideum)
        
        Actin:ADP [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        Mother filament:branching complex:daughter filament [cytosol] (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        Detachment of WASP/WAVE (Dictyostelium discoideum)
        
        Mother filament:ARP2/3:actin:ADP [cytosol] (Dictyostelium discoideum)
        
        Actin:ADP [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        Mother filament:branching complex [cytosol] (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
      - RHO GTPases activate IQGAPs (Dictyostelium discoideum)
        
        IQGAPs bind F-actin, which is inhibited by calmodulin (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane] (Dictyostelium discoideum)
        
        F-actin [cytosol] (Dictyostelium discoideum)
        
        G-actin [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
    - RHO GTPase cycle (Dictyostelium discoideum)
      - RHOBTB GTPase Cycle (Dictyostelium discoideum)
        
        RHOBTB2 GTPase cycle (Dictyostelium discoideum)
        
        RHOBTB2 binds interacting proteins at the endosome membrane (Dictyostelium discoideum)
        
        RHOBTB2 interacting proteins [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)
        
        RHOBTB2:GTP:RHOBTB2 interacting proteins [endosome membrane] (Dictyostelium discoideum)
        
        RHOBTB2 interacting proteins [cytosol] (Dictyostelium discoideum)
        
        Homologues of ACTB [cytosol] (Dictyostelium discoideum)
        
        act3 [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:P07829

Gene Names

act3

Reference Genes

BioGPS Gene:8627179 act3

dictyBase:DDB_G0289487

ENSEMBL:DDB_G0289487

KEGG:ddi:DDB_G0289487 act3

Monarch:8627179 act3

NCBI Gene:8627179 act3

UCSC:P07829 act3

Reference Transcript

RefSeq:XM_631100.1 act3

Participates

as a member of

Homologues of ACTB [cytosol] (Dictyostelium discoideum)

Other forms of this molecule

act3 [extracellular region]

act3 [nucleoplasm]

act3 [plasma membrane]

Inferred From

POTEKP [cytosol] (Homo sapiens)

ACTB [cytosol] (Homo sapiens)

ACTG1 [cytosol] (Homo sapiens)

Cross References

PRO

P07829

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