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phospho-p-T185,Y187-MAPK1 [cytosol]
Stable Identifier
R-DDI-109853
Type
Protein [EntityWithAccessionedSequence]
Species
Dictyostelium discoideum
Compartment
cytosol
Synonyms
Q55C57
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Dictyostelium discoideum)
Cellular responses to stress (Dictyostelium discoideum)
Cellular response to heat stress (Dictyostelium discoideum)
Regulation of HSF1-mediated heat shock response (Dictyostelium discoideum)
Constitutive phosphorylation by pERK1/2 (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Developmental Biology (Dictyostelium discoideum)
MITF-M-regulated melanocyte development (Dictyostelium discoideum)
Transcriptional and post-translational regulation of MITF-M expression and activity (Dictyostelium discoideum)
MAPK-dependent phosphorylation of KARS (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Nervous system development (Dictyostelium discoideum)
Axon guidance (Dictyostelium discoideum)
L1CAM interactions (Dictyostelium discoideum)
Recycling pathway of L1 (Dictyostelium discoideum)
Phosphorylation of L1 by ERK (Dictyostelium discoideum)
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Signal transduction by L1 (Dictyostelium discoideum)
MAP2K2 phosphorylates MAPK1 (Dictyostelium discoideum)
p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Immune System (Dictyostelium discoideum)
Innate Immune System (Dictyostelium discoideum)
Fcgamma receptor (FCGR) dependent phagocytosis (Dictyostelium discoideum)
Regulation of actin dynamics for phagocytic cup formation (Dictyostelium discoideum)
p-ERK phosphorylates WAVEs and ABI (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Signal Transduction (Dictyostelium discoideum)
MAPK family signaling cascades (Dictyostelium discoideum)
MAPK1/MAPK3 signaling (Dictyostelium discoideum)
RAF-independent MAPK1/3 activation (Dictyostelium discoideum)
Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
p-T,Y MAPK monomers and dimers [cytosol] (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
MAPK1 (ERK2) activation (Dictyostelium discoideum)
Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Dictyostelium discoideum)
p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
MAP2K2 phosphorylates MAPK1 (Dictyostelium discoideum)
p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Phosphorylated MAPKs translocate into the nucleus (Dictyostelium discoideum)
p-T,Y MAPK monomers and dimers [cytosol] (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs dimerize (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
RAF/MAP kinase cascade (Dictyostelium discoideum)
MAP2K and MAPK activation (Dictyostelium discoideum)
Dissociation of RAS:RAF complex (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Dictyostelium discoideum)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Dictyostelium discoideum)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
MAP2Ks phosphorylate MAPKs (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Dictyostelium discoideum)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Negative regulation of MAPK pathway (Dictyostelium discoideum)
Cytosolic DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
p-T,Y MAPK monomers and dimers [cytosol] (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Negative feedback regulation of MAPK pathway (Dictyostelium discoideum)
Activated MAPK phosphorylates RAF1 (Dictyostelium discoideum)
p-T,Y MAPK monomers and dimers [cytosol] (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Activated MAPKs phosphorylate BRAF (Dictyostelium discoideum)
p-T,Y MAPK monomers and dimers [cytosol] (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Activated MAPKs phosphorylate MAP2K1 (Dictyostelium discoideum)
p-T,Y MAPK monomers and dimers [cytosol] (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
PTPN7 binds p-T,Y-MAPK (Dictyostelium discoideum)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
PTPN7 dephosphorylates p-T,Y-MAPKs (Dictyostelium discoideum)
PTPN7:p-T,Y-MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Phosphorylated MAPKs translocate into the nucleus (Dictyostelium discoideum)
p-T,Y MAPK monomers and dimers [cytosol] (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs dimerize (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G alpha (i) signalling events (Dictyostelium discoideum)
Opioid Signalling (Dictyostelium discoideum)
G-protein mediated events (Dictyostelium discoideum)
PLC beta mediated events (Dictyostelium discoideum)
Ca-dependent events (Dictyostelium discoideum)
phospho-PLA2 pathway (Dictyostelium discoideum)
Phosphorylation of cPLA2 by ERK-2 (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Signaling by Nuclear Receptors (Dictyostelium discoideum)
ESR-mediated signaling (Dictyostelium discoideum)
Extra-nuclear estrogen signaling (Dictyostelium discoideum)
Estrogen-stimulated signaling through PRKCZ (Dictyostelium discoideum)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
Signaling by NTRKs (Dictyostelium discoideum)
Signaling by NTRK1 (TRKA) (Dictyostelium discoideum)
Signalling to ERKs (Dictyostelium discoideum)
Prolonged ERK activation events (Dictyostelium discoideum)
Frs2-mediated activation (Dictyostelium discoideum)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Dictyostelium discoideum)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPK dimers translocate to nucleus (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs dimerize (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Dictyostelium discoideum)
Signaling by Rho GTPases (Dictyostelium discoideum)
RHO GTPase Effectors (Dictyostelium discoideum)
RHO GTPases Activate WASPs and WAVEs (Dictyostelium discoideum)
p-ERK phosphorylates WAVEs and ABI (Dictyostelium discoideum)
p-T,Y MAPK dimers [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
phospho-p-T185,Y187-MAPK1 [cytosol] (Dictyostelium discoideum)
External Reference Information
External Reference
UniProt:Q55C57
Reference Genes
BioGPS Gene:8617596
dictyBase:DDB_G0270218
ENSEMBL:DDB_G0270218
KEGG:ddi:DDB_G0270218
Monarch:8617596
NCBI Gene:8617596
UCSC:Q55C57
Reference Transcript
RefSeq:XM_641532.1
Participates
as an input of
Phosphorylation of L1 by ERK (Dictyostelium discoideum)
as a component of
pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (Dictyostelium discoideum)
p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] (Dictyostelium discoideum)
p-T185,Y187 MAPK1 dimer [cytosol] (Dictyostelium discoideum)
as an output of
Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 (Dictyostelium discoideum)
as a member of
p-T,Y MAPKs [cytosol] (Dictyostelium discoideum)
Other forms of this molecule
MAPK1 [ficolin-1-rich granule lumen]
MAPK1 [extracellular region]
MAPK1 [azurophil granule lumen]
phospho-p-T202-MAPK3 [cytosol]
phospho-p-T185-MAPK1 [cytosol]
MAPK1 [nucleoplasm]
MAPK3 [nucleoplasm]
MAPK3 [cytosol]
MAPK1 [cytosol]
phospho-p-T202,Y204-MAPK3 [cytosol]
phospho-p-T202,Y204-MAPK3 [nucleoplasm]
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
Inferred From
p-T185,Y187-MAPK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 185 (in Homo sapiens)
Coordinate
185
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at 187 (in Homo sapiens)
Coordinate
187
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
PRO
Q55C57
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