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SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane]
Stable Identifier
R-COV-9694458
Type
Complex
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
double membrane vesicle viral factory outer membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
SARS-CoV-2 Genome Replication and Transcription (Homo sapiens)
Replication of the SARS-CoV-2 genome (Homo sapiens)
RTC completes synthesis of the minus strand genomic RNA complement (Homo sapiens)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:RNA primer binds RTC inhibitors (Homo sapiens)
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors (Homo sapiens)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp12 misincorporates a nucleotide in nascent RNA minus strand (Homo sapiens)
SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement (Homo sapiens)
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template (Homo sapiens)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA (Homo sapiens)
SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp15 cleaves viral poly(U)-RNA (Homo sapiens)
SARS-CoV-2 dsRNA with poly(U)-containing (-) strand:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC: 5'-poly(U) RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
nsp8 generates RNA primers (Homo sapiens)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
Transcription of SARS-CoV-2 sgRNAs (Homo sapiens)
Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching (Homo sapiens)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
CNBP binds SARS-CoV-2 G-rich RNA (Homo sapiens)
CNBP:SARS-CoV-2 G-rich RNA:RTC [double membrane vesicle viral factory outer membrane] (Homo sapiens)
SARS-CoV-2 G-rich RNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 G-rich RNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
DDX58 binds SARS-CoV-2 dsRNA intermediates (Homo sapiens)
SARS-CoV-2 dsRNA intermediates:DDX58 [double membrane vesicle viral factory outer membrane] (Homo sapiens)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates (Homo sapiens)
SARS-CoV-2 dsRNA intermediates:IFIH1 [double membrane vesicle viral factory outer membrane] (Homo sapiens)
SARS-CoV-2 dsRNA with poly(U)-containing (-) strand:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC: 5'-poly(U) RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 dsRNA with poly(U)-containing (-) strand:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC: 5'-poly(U) RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
LARP1 binds SARS-CoV-2 RNA (Homo sapiens)
LARP1:SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Homo sapiens)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
General
This COVID-19 Complex instance was generated via electronic inference from a curated CoV-1 (Human SARS coronavirus) Reactome instance. In Reactome, inference is the process used to automatically create orthologous Pathways, Reactions and PhysicalEntities from our expertly curated data (https://reactome.org/documentation/inferred-events).
Participants
components
m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) [cytosol]
(Severe acute respiratory syndrome coronavirus 2)
RTC [double membrane vesicle viral factory outer membrane]
(Severe acute respiratory syndrome coronavirus 2)
Participates
as a component of
SARS-CoV-2 gRNA:RTC: 5'-poly(U) RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
LARP1:SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane] (Homo sapiens)
SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
as an input of
LARP1 binds SARS-CoV-2 RNA (Homo sapiens)
nsp8 generates RNA primers (Homo sapiens)
Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching (Homo sapiens)
as a member of
SARS-CoV-2 G-rich RNA:RTC [double membrane vesicle viral factory outer membrane] (Severe acute respiratory syndrome coronavirus 2)
as an output of
nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template (Homo sapiens)
Inferred From
SARS-CoV-1 gRNA:RTC [double membrane vesicle viral factory outer membrane]
(Human SARS coronavirus)
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
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