Reactome | CD274 [cytosol]

CD274 [cytosol]

Stable Identifier

R-CFA-9925063

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

CD274, E2RKZ5

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Regulation of T cell activation by CD28 family (Canis familiaris)
    - Co-inhibition by PD-1 (Canis familiaris)
      - Regulation of PD-L1(CD274) expression (Canis familiaris)
        
        Regulation of PD-L1(CD274) Post-translational modification (Canis familiaris)
        
        SPOP-mediated proteasomal degradation of PD-L1(CD274) (Canis familiaris)
        
        CD274 ubiquitination by SPOP:CUL3:RBX1 complex (Canis familiaris)
        
        SPOP:CUL3:RBX1:CD274 [cytosol] (Canis familiaris)
        
        CD274 [cytosol] (Canis familiaris)
        
        polyUb-PDL1:SPOP:CUL3:RBX1 [cytosol] (Canis familiaris)
        
        SPOP:CUL3:RBX1:CD274 [cytosol] (Canis familiaris)
        
        CD274 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2RKZ5

Gene Names

CD274

Reference Genes

BioGPS Gene:484186 CD274

ENSEMBL:ENSCAFG00845016107.1

KEGG:cfa:484186 CD274

Monarch:484186 CD274

NCBI Gene:484186 CD274

UCSC:E2RKZ5 CD274

Reference Transcript

RefSeq:NM_001291972.1 CD274

Other Identifiers

484186

CfaAffx.4085.1.S1_at

CfaAffx.4086.1.S1_s_at

GO:0002250

GO:0002376

GO:0005768

GO:0005886

GO:0009897

GO:0016020

GO:0031901

GO:0042130

GO:0055038

Participates

as a component of

SPOP:CUL3:RBX1:CD274 [cytosol] (Canis familiaris)

Other forms of this molecule

CD274 [plasma membrane]

CD274 [Golgi membrane]

phospho-CD274 [endoplasmic reticulum membrane]

phospho-CD274 [cytosol]

phospho-CD274 [endoplasmic reticulum membrane]

CD274 [endoplasmic reticulum membrane]

phospho-CD274 [cytosol]

phospho-CD274 [endoplasmic reticulum membrane]

Inferred From

CD274 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001278901.1

ENSEMBL

ENSCAFT00845028674, ENSCAFP00845022568, ENSCAFG00845016107

VGNC

38942

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