Reactome | DLA-12 [lumenal side of endoplasmic reticulum membrane]

DLA-12 [lumenal side of endoplasmic reticulum membrane]

Stable Identifier

R-CFA-983093-4

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

lumenal side of endoplasmic reticulum membrane

Synonyms

HLA class I histocompatibility antigen, alpha chain F precursor, A0A8I3NSU2

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Class I MHC mediated antigen processing & presentation (Canis familiaris)
    - Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Canis familiaris)
      - Binding of newly synthesized MHC class I heavy chain (HC) with calnexin (Canis familiaris)
        
        monoglucosylated MHC class I HC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Homologues of HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        DLA-12 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        monoglucosylated MHC class I HC:Calnexin/BiP [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        monoglucosylated MHC class I HC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Homologues of HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        DLA-12 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
      - Budding of COPII coated vesicle (Canis familiaris)
        
        COPII vesicle with MHC class I [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Peptide bound class I MHC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        monoglucosylated MHC class I HC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Homologues of HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        DLA-12 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
      - Interaction of beta-2-microglobulin (B2M) chain with class I HC (Canis familiaris)
        
        MHC HC:B2M:Erp57 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        monoglucosylated MHC class I HC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Homologues of HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        DLA-12 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        MHC class I HC:Calnexin/BiP:Erp57 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        monoglucosylated MHC class I HC:Calnexin/BiP [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        monoglucosylated MHC class I HC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Homologues of HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        DLA-12 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
      - Loading of antigenic peptides on to class I MHC (Canis familiaris)
        
        Antigenic peptide:MHC:B2M peptide loading complex [endoplasmic reticulum membrane] (Canis familiaris)
        
        MHC:B2M peptide loading complex [endoplasmic reticulum membrane] (Canis familiaris)
        
        MHC HC:B2M:Erp57 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        monoglucosylated MHC class I HC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Homologues of HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        DLA-12 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        MHC:B2M peptide loading complex [endoplasmic reticulum membrane] (Canis familiaris)
        
        MHC HC:B2M:Erp57 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        monoglucosylated MHC class I HC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Homologues of HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        DLA-12 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
      - Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Canis familiaris)
        
        COPII vesicle with MHC class I [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Peptide bound class I MHC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        monoglucosylated MHC class I HC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Homologues of HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        DLA-12 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Peptide bound class I MHC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        monoglucosylated MHC class I HC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Homologues of HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        DLA-12 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
      - Transport of MHC heterotrimer to ER exit site (Canis familiaris)
        
        Antigen peptide bound class I MHC:BAP31 oligomer [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Peptide bound class I MHC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        monoglucosylated MHC class I HC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Homologues of HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        DLA-12 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Peptide bound class I MHC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        monoglucosylated MHC class I HC [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        Homologues of HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)
        
        DLA-12 [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NSU2

Gene Names

DLA-12

Reference Genes

ENSEMBL:ENSCAFG00845017245.1

UCSC:A0A8I3NSU2 DLA-12

Other Identifiers

541592

Cfa.20996.1.S1_at

Cfa.280.1.S1_s_at

CfaAffx.1697.1.S1_s_at

GO:0002376

GO:0002474

GO:0006955

GO:0016020

GO:0019882

GO:0030670

GO:0042612

GO:0098553

Participates

as a member of

Homologues of HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Canis familiaris)

Other forms of this molecule

DLA-12 [phagocytic vesicle membrane]

DLA-12 [recycling endosome membrane]

DLA-12 [early endosome membrane]

DLA-12 [ER to Golgi transport vesicle membrane]

DLA-12 [plasma membrane]

DLA-12 [Golgi membrane]

DLA-12 [azurophil granule membrane]

DLA-12 [secretory granule membrane]

DLA-12 [plasma membrane]

DLA-12 [lumenal side of endoplasmic reticulum membrane]

Inferred From

HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFG00845017245, ENSCAFP00845023931, ENSCAFT00845030509

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