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STUB1 [cytosol]
Stable Identifier
R-CFA-975970
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
STUB1, A0A8I3PT83
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional regulation by RUNX2 (Canis familiaris)
Regulation of RUNX2 expression and activity (Canis familiaris)
RUNX2 binds STUB1 (Canis familiaris)
RUNX2:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
STUB1 polyubiquitinates RUNX2 (Canis familiaris)
RUNX2:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
Release of E3 from polyubiquitinated substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
Programmed Cell Death (Canis familiaris)
Regulated Necrosis (Canis familiaris)
RIPK1-mediated regulated necrosis (Canis familiaris)
Regulation of necroptotic cell death (Canis familiaris)
RIPK3 binds STUB1 (Canis familiaris)
RIPK3:STUB1 [cytosol] (Canis familiaris)
STUB1:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
STUB1:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
STUB1 ubiquitinates RIPK3 at K55, K363 (Canis familiaris)
RIPK3:STUB1 [cytosol] (Canis familiaris)
STUB1:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
STUB1:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
Ub-K55,363-RIPK3:STUB1 [cytosol] (Canis familiaris)
STUB1:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
RIPK1 binds STUB1 (Canis familiaris)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Canis familiaris)
STUB1:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
STUB1:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
STUB1 ubiquitinates RIPK1 at K571, K604, K627 (Canis familiaris)
RIPK1:STUB1:Ub:UBE2D3 [cytosol] (Canis familiaris)
STUB1:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
STUB1:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
PTEN Regulation (Canis familiaris)
Regulation of PTEN stability and activity (Canis familiaris)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Canis familiaris)
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
Downregulation of ERBB2 signaling (Canis familiaris)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Downregulation of TGF-beta receptor signaling (Canis familiaris)
SMAD3 binds STUB1 (CHIP) (Canis familiaris)
SMAD3:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
STUB1 (CHIP) ubiquitinates SMAD3 (Canis familiaris)
SMAD3:STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
STUB1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PT83
Gene Names
STUB1
Reference Genes
BioGPS Gene:479892 STUB1
ENSEMBL:ENSCAFG00845026980.1
KEGG:cfa:479892 STUB1
Monarch:479892 STUB1
NCBI Gene:479892 STUB1
UCSC:A0A8I3PT83 STUB1
Reference Transcript
RefSeq:XM_038669705.1 STUB1
RefSeq:XM_038540905.1 STUB1
RefSeq:XM_038551199.1 STUB1
Other Identifiers
479892
Cfa.12154.1.A1_at
CfaAffx.30010.1.S1_s_at
GO:0000151
GO:0000209
GO:0001664
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005829
GO:0006281
GO:0006511
GO:0006513
GO:0006515
GO:0006974
GO:0007165
GO:0009893
GO:0016567
GO:0016740
GO:0019899
GO:0019900
GO:0030018
GO:0030163
GO:0030512
GO:0030544
GO:0030911
GO:0030968
GO:0031072
GO:0031398
GO:0031625
GO:0031647
GO:0031943
GO:0032436
GO:0034392
GO:0034450
GO:0035359
GO:0036503
GO:0042405
GO:0042803
GO:0043161
GO:0045862
GO:0046332
GO:0050821
GO:0051087
GO:0051787
GO:0051865
GO:0051879
GO:0061630
GO:0070412
GO:0070534
GO:0071218
GO:0090035
GO:0101031
GO:0140096
GO:1904294
Participates
as an input of
RUNX2 binds STUB1 (Canis familiaris)
SMAD3 binds STUB1 (CHIP) (Canis familiaris)
as an output of
STUB1 polyubiquitinates RUNX2 (Canis familiaris)
STUB1 (CHIP) ubiquitinates SMAD3 (Canis familiaris)
as a component of
RUNX2:STUB1 [cytosol] (Canis familiaris)
STUB1:STUB1 [cytosol] (Canis familiaris)
SMAD3:STUB1 [cytosol] (Canis familiaris)
as a member of
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Canis familiaris)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
Inferred From
STUB1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_038525633.1
,
XP_038396833.1
,
XP_038407127.1
ENSEMBL
ENSCAFP00845037301
,
ENSCAFG00845026980
,
ENSCAFT00845047539
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