Reactome | phospho-TIFA [cytosol]

phospho-TIFA [cytosol]

Stable Identifier

R-CFA-9645512

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

p-T9-TIFA, A0A8I3NQX5

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-1 family signaling (Canis familiaris)
      - Interleukin-1 signaling (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Alpha-protein kinase 1 signaling pathway (Canis familiaris)
    - ALPK1 phosphorylates TIFA (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - TIFA oligomerization (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA dimer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
      - ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:p-T184,T187-TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] (Canis familiaris)
        
        ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] (Canis familiaris)
        
        p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)
        
        phospho-TIFA [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NQX5

Gene Names

TIFA

Reference Genes

BioGPS Gene:487905 TIFA

ENSEMBL:ENSCAFG00845016552.1

KEGG:cfa:487905 TIFA

Monarch:487905 TIFA

NCBI Gene:487905 TIFA

UCSC:A0A8I3NQX5 TIFA

Reference Transcript

Other Identifiers

487905

CfaAffx.18103.1.S1_at

GO:0002376

GO:0002753

GO:0005515

GO:0005737

GO:0033209

GO:0043123

GO:0045087

GO:0051260

GO:0065003

GO:0098542

Participates

as a component of

p-T9-TIFA:p-T9-TIFA [cytosol] (Canis familiaris)

Other forms of this molecule

TIFA [cytosol]

Inferred From

p-T9-TIFA [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 9 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_005639340.1, XP_038300339.1, XP_038300338.1, XP_013965440.1, XP_038437822.1, XP_038437821.1, XP_038317930.1, XP_038437820.1, XP_038300337.1

ENSEMBL

ENSCAFG00845016552, ENSCAFT00845029342, ENSCAFP00845023085, ENSCAFT00845029371, ENSCAFP00845023068

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