Reactome | ERAD complex [endoplasmic reticulum membrane]

ERAD complex [endoplasmic reticulum membrane]

Stable Identifier

R-CFA-8866531

Type

Complex

Species

Canis familiaris

Compartment

endoplasmic reticulum membrane

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

DERL oligomer [endoplasmic reticulum membrane] (Canis familiaris)
ERLIN1:ERLIN2 [endoplasmic reticulum membrane] (Canis familiaris)
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Canis familiaris)
RNF5 [endoplasmic reticulum membrane] (Canis familiaris)
SEL1L [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)

Participates

as an input of

CFTR binds components of the ERAD machinery for ubiquitination and degradation (Canis familiaris)

as an output of

VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)

as a component of

misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)

Inferred From

ERAD complex [endoplasmic reticulum membrane] (Homo sapiens)

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