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EIF2S3 [cytosol]
Stable Identifier
R-CFA-72514
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
EIF2S3, A0A8I3Q3Z7
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to mitochondrial stress (Canis familiaris)
DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
Unfolded Protein Response (UPR) (Canis familiaris)
PERK regulates gene expression (Canis familiaris)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Translation (Canis familiaris)
Eukaryotic Translation Initiation (Canis familiaris)
Cap-dependent Translation Initiation (Canis familiaris)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Canis familiaris)
Translation initiation complex formation (Canis familiaris)
Formation of translation initiation complexes containing mRNA that does not circularize (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
ternary complex [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
ternary complex [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
ternary complex [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
ternary complex [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
Formation of the ternary complex, and subsequently, the 43S complex (Canis familiaris)
De novo formation of eIF2:GTP (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
Formation of the 43S pre-initiation complex (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
ternary complex [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
ternary complex [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
Met-tRNAi binds to eIF2:GTP to form the ternary complex (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
ternary complex [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
GTP hydrolysis and joining of the 60S ribosomal subunit (Canis familiaris)
eIF2:GTP is hydrolyzed, eIFs are released (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
ternary complex [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
eIF2:GDP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
Recycling of eIF2:GDP (Canis familiaris)
Formation of eIF2:GDP:eIF2B intermediate (Canis familiaris)
eIF2:GDP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
eIF2:GDP: eIF2B [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
eIF2 activation (Canis familiaris)
eIF2:GDP: eIF2B [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
Ribosomal scanning and start codon recognition (Canis familiaris)
Ribosomal scanning (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
ternary complex [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
Start codon recognition (Canis familiaris)
48S complex [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
ternary complex [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
L13a-mediated translational silencing of Ceruloplasmin expression (Canis familiaris)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
ternary complex [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Canis familiaris)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
43S complex [cytosol] (Canis familiaris)
ternary complex [cytosol] (Canis familiaris)
eIF2:GTP [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
ABCF1 binds EIF2 (Canis familiaris)
ABCF1:EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3Q3Z7
Gene Names
EIF2S3
Reference Genes
ENSEMBL:ENSCAFG00845030382.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845030382.1 EIF2S3
Other Identifiers
119868410
Cfa.10883.1.S1_at
Cfa.1410.1.A1_at
CfaAffx.20766.1.S1_s_at
GO:0000049
GO:0003723
GO:0003824
GO:0003924
GO:0005525
GO:0016787
Participates
as a component of
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
Inferred From
EIF2S3 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000130741
Ensembl
ENSCAFG00845030382
,
ENSCAFT00845053910
,
ENSCAFP00845042364
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