Reactome | LOC119868749 [cytosol]

LOC119868749 [cytosol]

Stable Identifier

R-CFA-72514

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

EIF2S3, A0A8I3P243

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Canis familiaris)

- Translation (Canis familiaris)
  - Eukaryotic Translation Initiation (Canis familiaris)
    - Cap-dependent Translation Initiation (Canis familiaris)
      - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Canis familiaris)
        
        Translation initiation complex formation (Canis familiaris)
        
        Formation of translation initiation complexes containing mRNA that does not circularize (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        ternary complex [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        48S complex [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        ternary complex [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        ternary complex [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        ternary complex [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
      - Formation of the ternary complex, and subsequently, the 43S complex (Canis familiaris)
        
        De novo formation of eIF2:GTP (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        Formation of the 43S pre-initiation complex (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        ternary complex [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        ternary complex [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        Met-tRNAi binds to eIF2:GTP to form the ternary complex (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        ternary complex [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Canis familiaris)
        
        eIF2:GTP is hydrolyzed, eIFs are released (Canis familiaris)
        
        48S complex [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        ternary complex [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        eIF2:GDP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
      - Recycling of eIF2:GDP (Canis familiaris)
        
        Formation of eIF2:GDP:eIF2B intermediate (Canis familiaris)
        
        eIF2:GDP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        eIF2:GDP: eIF2B [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        eIF2 activation (Canis familiaris)
        
        eIF2:GDP: eIF2B [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
      - Ribosomal scanning and start codon recognition (Canis familiaris)
        
        Ribosomal scanning (Canis familiaris)
        
        48S complex [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        ternary complex [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        Start codon recognition (Canis familiaris)
        
        48S complex [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        ternary complex [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Canis familiaris)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        ternary complex [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Canis familiaris)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        ternary complex [cytosol] (Canis familiaris)
        
        eIF2:GTP [cytosol] (Canis familiaris)
        
        EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)

Transport of small molecules (Canis familiaris)

- ABC-family protein mediated transport (Canis familiaris)
  - ABCF1 binds EIF2 (Canis familiaris)
    - ABCF1:EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
      - EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
        
        Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)
    - EIF2S1:EIF2S2:EIF2S3 [cytosol] (Canis familiaris)
      - Homologues of EIF2S3 [cytosol] (Canis familiaris)
        
        LOC119868749 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3P243

Gene Names

LOC119868749

Reference Genes

BioGPS Gene:119868749 LOC119868749

ENSEMBL:ENSCAFG00845020384.1

Monarch:119868749 LOC119868749

NCBI Gene:119868749 LOC119868749

UCSC:A0A8I3P243 LOC119868749

Reference Transcript

RefSeq:XM_038451379.1 LOC119868749

Other Identifiers

119868749

Cfa.9060.1.A1_at

GO:0000049

GO:0003723

GO:0003924

GO:0005525

GO:0016787

Participates

as a member of

Homologues of EIF2S3 [cytosol] (Canis familiaris)

Inferred From

EIF2S3 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038307307.1

ENSEMBL

ENSCAFP00845028093, ENSCAFT00845035900, ENSCAFG00845020384

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