Reactome | UBA52 [cytosol]

UBA52 [cytosol]

Stable Identifier

R-CFA-72476

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

RPL40, P63050

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Canis familiaris)

- Nonsense-Mediated Decay (NMD) (Canis familiaris)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        UBA52 [cytosol] (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        UBA52 [cytosol] (Canis familiaris)
    - SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        UBA52 [cytosol] (Canis familiaris)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        UBA52 [cytosol] (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        UBA52 [cytosol] (Canis familiaris)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        UBA52 [cytosol] (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        UBA52 [cytosol] (Canis familiaris)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Canis familiaris)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        UBA52 [cytosol] (Canis familiaris)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        UBA52 [cytosol] (Canis familiaris)
- rRNA processing (Canis familiaris)
  - rRNA processing in the nucleus and cytosol (Canis familiaris)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Canis familiaris)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Canis familiaris)
        
        60S ribosomal complex [cytosol] (Canis familiaris)
        
        UBA52 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:P63050

Gene Names

UBA52

Reference Genes

BioGPS Gene:403722 UBA52

ENSEMBL:ENSCAFG00845020932

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000014723.5 UBA52

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030016247.1 UBA52

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040016838.1 UBA52

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040023038.1 UBA52

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00805020732 UBA52

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845020932.1 UBA52

KEGG Gene (Canis lupus familiaris):403722 UBA52

Monarch:403722 UBA52

NCBI Gene:403722 UBA52

Reference Transcript

Other Identifiers

403722

Cfa.3552.1.S1_s_at

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005783

GO:0005829

GO:0005840

GO:0005886

GO:0006412

GO:0022625

GO:0022626

GO:0043226

Participates

as an output of

UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Canis familiaris)

as a component of

Other forms of this molecule

UBA52 [mitochondrial outer membrane]

UBA52 [cytosol]

phospho-UBA52 [nucleoplasm]

UBA52 [cytosol]

phospho-UBA52 [cytosol]

UBA52 [endosome membrane]

UBA52 [cytosol]

UBA52 [nucleoplasm]

UBA52 [cytosol]

UBA52 [nucleoplasm]

UBA52 [cytosol]

Inferred From

RPL40 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_013977202.1, NP_001121567.1, XP_005632363.1

OpenTargets

ENSG00000221983

Ensembl

ENSCAFT00845036939, ENSCAFG00845020932, ENSCAFP00845028922

VGNC

59398

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