Reactome | RPS3A [cytosol]

RPS3A [cytosol]

Stable Identifier

R-CFA-72373

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

RPS3A, A0A8I3MUG5

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Canis familiaris)

- Nonsense-Mediated Decay (NMD) (Canis familiaris)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3A [cytosol] (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3A [cytosol] (Canis familiaris)
    - SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3A [cytosol] (Canis familiaris)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3A [cytosol] (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3A [cytosol] (Canis familiaris)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3A [cytosol] (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3A [cytosol] (Canis familiaris)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Canis familiaris)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3A [cytosol] (Canis familiaris)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS3A [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MUG5

Gene Names

RPS3A

Reference Genes

BioGPS Gene:403677 RPS3A

ENSEMBL:ENSCAFG00845005765.1

KEGG:cfa:403677 RPS3A

Monarch:403677 RPS3A

NCBI Gene:403677 RPS3A

UCSC:A0A8I3MUG5 RPS3A

Other Identifiers

403677

Cfa.3544.1.S2_at

CfaAffx.11621.1.S1_s_at

GO:0003735

GO:0005198

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0022627

GO:0030154

GO:1990904

Participates

as a component of

Other forms of this molecule

RPS3A [nucleoplasm]

Inferred From

RPS3A [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038544534.1, XP_005629388.1, XP_038414941.1

ENSEMBL

ENSCAFT00845010212, ENSCAFP00845007958, ENSCAFG00845005765

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