Reactome | RPS21 [cytosol]

RPS21 [cytosol]

Stable Identifier

R-CFA-72351

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

RPS21, A0A8I3NWI3

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Canis familiaris)

- Nonsense-Mediated Decay (NMD) (Canis familiaris)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
    - SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Canis familiaris)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)

Metabolism of proteins (Canis familiaris)

- Translation (Canis familiaris)
  - Eukaryotic Translation Initiation (Canis familiaris)
    - Cap-dependent Translation Initiation (Canis familiaris)
      - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Canis familiaris)
        
        Translation initiation complex formation (Canis familiaris)
        
        Formation of translation initiation complexes containing mRNA that does not circularize (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        48S complex [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
      - Formation of a pool of free 40S subunits (Canis familiaris)
        
        Release of 40S and 60S subunits from the 80S ribosome (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        eIF3 and eIF1A bind to the 40S subunit (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        40S:eIF3:eIF1A [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
      - Formation of the ternary complex, and subsequently, the 43S complex (Canis familiaris)
        
        Formation of the 43S pre-initiation complex (Canis familiaris)
        
        40S:eIF3:eIF1A [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Canis familiaris)
        
        The 60S subunit joins the translation initiation complex (Canis familiaris)
        
        40S:Met-tRNAi:mRNA [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        eIF2:GTP is hydrolyzed, eIFs are released (Canis familiaris)
        
        40S:Met-tRNAi:mRNA [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        48S complex [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        eIF5B:GTP is hydrolyzed and released (Canis familiaris)
        
        80S:Met-tRNAi:mRNA [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
      - Ribosomal scanning and start codon recognition (Canis familiaris)
        
        Ribosomal scanning (Canis familiaris)
        
        48S complex [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        Start codon recognition (Canis familiaris)
        
        48S complex [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Canis familiaris)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Canis familiaris)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Canis familiaris)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Canis familiaris)
        
        43S complex [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
  - Ribosome-associated quality control (Canis familiaris)
    - PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA (Canis familiaris)
      - ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released (Canis familiaris)
        
        ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Canis familiaris)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
    - ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA (Canis familiaris)
      - RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide (Canis familiaris)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
        
        K63polyUb-80S ribosome [cytosol] (Canis familiaris)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide [cytosol] (Canis familiaris)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
        
        K63polyUb-80S ribosome [cytosol] (Canis familiaris)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
      - ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit (Canis familiaris)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
        
        K63polyUb-80S ribosome [cytosol] (Canis familiaris)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Canis familiaris)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
      - ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome (Canis familiaris)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
        
        ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Canis familiaris)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
  - SRP-dependent cotranslational protein targeting to membrane (Canis familiaris)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Canis familiaris)
      - SRP:polypeptide+signal:ribosome [cytosol] (Canis familiaris)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        Homologues of RPS21 [cytosol] (Canis familiaris)
        
        RPS21 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NWI3

Gene Names

RPS21

Reference Genes

BioGPS Gene:485959 RPS21

ENSEMBL:ENSCAFG00845016932.1

KEGG:cfa:485959 RPS21

Monarch:485959 RPS21

NCBI Gene:485959 RPS21

UCSC:A0A8I3NWI3 RPS21

Other Identifiers

119876172

485959

Cfa.802.2.S1_s_at

GO:0002181

GO:0003735

GO:0005198

GO:0005783

GO:0005791

GO:0005829

GO:0005840

GO:0006412

GO:0022626

GO:0022627

GO:0045202

GO:1990904

Participates

as a member of

Homologues of RPS21 [cytosol] (Canis familiaris)

Other forms of this molecule

RPS21 [nucleoplasm]

Inferred From

RPS21 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038313797.1, XP_038428729.1, XP_038290213.1

ENSEMBL

ENSCAFP00845023542, ENSCAFT00845030005, ENSCAFG00845016932

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