Reactome | RPS13 [cytosol]

RPS13 [cytosol]

Stable Identifier

R-CFA-72331

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

RPS13, A0A8I3Q153

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Canis familiaris)

- Nonsense-Mediated Decay (NMD) (Canis familiaris)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS13 [cytosol] (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS13 [cytosol] (Canis familiaris)
    - SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS13 [cytosol] (Canis familiaris)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS13 [cytosol] (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS13 [cytosol] (Canis familiaris)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS13 [cytosol] (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS13 [cytosol] (Canis familiaris)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Canis familiaris)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS13 [cytosol] (Canis familiaris)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Canis familiaris)
        
        80S ribosome [cytosol] (Canis familiaris)
        
        40S ribosomal complex [cytosol] (Canis familiaris)
        
        RPS13 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3Q153

Gene Names

RPS13

Reference Genes

BioGPS Gene:610820 RPS13

ENSEMBL:ENSCAFG00845026930.1

KEGG:cfa:610820 RPS13

Monarch:610820 RPS13

NCBI Gene:610820 RPS13

UCSC:A0A8I3Q153 RPS13

Reference Transcript

Other Identifiers

480235

610820

Cfa.3205.1.A1_s_at

CfaAffx.13722.1.S1_at

GO:0003729

GO:0003735

GO:0005198

GO:0005634

GO:0005730

GO:0005840

GO:0006412

GO:0014069

GO:0022626

GO:0022627

GO:0032040

GO:0033119

GO:0042274

GO:0043226

GO:0048027

GO:0070181

GO:1990904

Participates

as a component of

Other forms of this molecule

RPS13 [nucleoplasm]

Inferred From

RPS13 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038425095.1, XP_864902.1, XP_038286547.1

ENSEMBL

ENSCAFP00845037256, ENSCAFT00845047485, ENSCAFG00845026930

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