Reactome | FUS [nucleoplasm]

FUS [nucleoplasm]

Stable Identifier

R-CFA-72040

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

FUS, A0A8I3NWH7

Locations in the PathwayBrowser

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Metabolism of RNA (Canis familiaris)

- Processing of Capped Intron-Containing Pre-mRNA (Canis familiaris)
  - Formation of pre-mRNPs (Canis familiaris)
    - Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
      - FUS [nucleoplasm] (Canis familiaris)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
      - Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
  - mRNA 3'-end processing (Canis familiaris)
    - mRNA Polyadenylation (Canis familiaris)
      - Core CPA complex binds capped pre-mRNA (Canis familiaris)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
      - PP1 dephosphorylates RNA Pol II (Canis familiaris)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
      - RBBP6 activates CPSF complex (Canis familiaris)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Canis familiaris)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
  - mRNA Splicing (Canis familiaris)
    - mRNA Splicing - Major Pathway (Canis familiaris)
      - Formation of the Spliceosomal C complex containing intron lariat (Canis familiaris)
        
        Spliceosomal B* complex [nucleoplasm] (Canis familiaris)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
        
        Spliceosomal C complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
      - Formation of the Spliceosomal C* complex (Canis familiaris)
        
        Spliceosomal C complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
        
        Spliceosomal C* complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
      - Formation of the Spliceosomal P complex and exon ligation (Canis familiaris)
        
        Spliceosomal C* complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)
        
        Spliceosomal P complex [nucleoplasm] (Canis familiaris)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        FUS [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NWH7

Gene Names

FUS

Reference Genes

ENSEMBL:ENSCAFG00845011986.1

UCSC:A0A8I3NWH7 FUS

Other Identifiers

100856381

Cfa.20794.1.S1_at

Cfa.20794.1.S1_s_at

Cfa.245.1.S1_at

Cfa.245.1.S1_s_at

GO:0003676

GO:0003677

GO:0003682

GO:0003713

GO:0003723

GO:0003730

GO:0005634

GO:0005654

GO:0005737

GO:0006355

GO:0006357

GO:0008270

GO:0008380

GO:0010467

GO:0042802

GO:0043484

GO:0046872

GO:0048255

GO:0051260

GO:0060090

GO:0065003

GO:0098978

GO:0098982

GO:0099523

GO:0099524

GO:0140693

GO:0140694

GO:1905168

GO:1990000

Participates

as a member of

Alternative Splicing Factors [nucleoplasm] (Canis familiaris)

Inferred From

FUS [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFG00845011986, ENSCAFT00845021376, ENSCAFP00845016808

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