Reactome | SRSF1 [nucleoplasm]

SRSF1 [nucleoplasm]

Stable Identifier

R-CFA-72031

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

SRSF1, A0A8I3NX98

Locations in the PathwayBrowser

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Metabolism of RNA (Canis familiaris)

- Processing of Capped Intron-Containing Pre-mRNA (Canis familiaris)
  - Formation of pre-mRNPs (Canis familiaris)
    - Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
      - shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
      - Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
  - mRNA 3'-end processing (Canis familiaris)
    - TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Canis familiaris)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
      - Spliced mRNP [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
    - mRNA Polyadenylation (Canis familiaris)
      - Core CPA complex binds capped pre-mRNA (Canis familiaris)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
      - PP1 dephosphorylates RNA Pol II (Canis familiaris)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
      - RBBP6 activates CPSF complex (Canis familiaris)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Canis familiaris)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Canis familiaris)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
  - mRNA Splicing (Canis familiaris)
    - mRNA Splicing - Major Pathway (Canis familiaris)
      - Formation of the Spliceosomal C complex containing intron lariat (Canis familiaris)
        
        Spliceosomal B* complex [nucleoplasm] (Canis familiaris)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
        
        Spliceosomal C complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
      - Formation of the Spliceosomal C* complex (Canis familiaris)
        
        Spliceosomal C complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
        
        Spliceosomal C* complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
      - Formation of the Spliceosomal P complex and exon ligation (Canis familiaris)
        
        Spliceosomal C* complex [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
        
        Spliceosomal P complex [nucleoplasm] (Canis familiaris)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Canis familiaris)
        
        Alternative Splicing Factors [nucleoplasm] (Canis familiaris)
        
        shuttling SRSFs [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
    - mRNA Splicing - Minor Pathway (Canis familiaris)
      - ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Canis familiaris)
        
        ATAC C Complex [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
        
        post exon ligation complex [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
      - ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Canis familiaris)
        
        ATAC C Complex [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
      - Formation of AT-AC B Complex (Canis familiaris)
        
        ATAC A Complex [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
        
        ATAC B Complex [nucleoplasm] (Canis familiaris)
        
        ATAC A Complex [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
      - Formation of AT-AC C complex (Canis familiaris)
        
        ATAC B Complex [nucleoplasm] (Canis familiaris)
        
        ATAC A Complex [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)
        
        ATAC C Complex [nucleoplasm] (Canis familiaris)
        
        SRSF1 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NX98

Gene Names

SRSF1

Reference Genes

ENSEMBL:ENSCAFG00845017208.1

UCSC:A0A8I3NX98 SRSF1

Other Identifiers

609693

Cfa.20238.1.S1_at

Cfa.20238.2.A1_at

Cfa.21121.1.S1_at

CfaAffx.26676.1.S1_s_at

GO:0000380

GO:0000381

GO:0000395

GO:0001701

GO:0003012

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0005654

GO:0005737

GO:0006397

GO:0008380

GO:0016071

GO:0016607

GO:0023019

GO:0034504

GO:0035145

GO:0043484

GO:0044547

GO:0048255

GO:0048856

GO:0050733

GO:0060048

GO:0065003

GO:0071013

GO:0097398

GO:0097400

GO:0110012

Participates

as a component of

as a member of

shuttling SRSFs [nucleoplasm] (Canis familiaris)

Inferred From

SRSF1 [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFP00845023966, ENSCAFG00845017208, ENSCAFT00845030551

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