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26S proteasome [cytosol]
Stable Identifier
R-CFA-68819
Type
Complex
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Canis familiaris)
Cell Cycle Checkpoints (Canis familiaris)
G1/S DNA Damage Checkpoints (Canis familiaris)
p53-Dependent G1/S DNA damage checkpoint (Canis familiaris)
p53-Dependent G1 DNA Damage Response (Canis familiaris)
Stabilization of p53 (Canis familiaris)
Autodegradation of the E3 ubiquitin ligase COP1 (Canis familiaris)
Proteasome mediated degradation of COP1 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
p53-Independent G1/S DNA damage checkpoint (Canis familiaris)
p53-Independent DNA Damage Response (Canis familiaris)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Canis familiaris)
Proteolytic degradation of ubiquitinated-Cdc25A (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
G2/M Checkpoints (Canis familiaris)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Cell Cycle, Mitotic (Canis familiaris)
M Phase (Canis familiaris)
Mitotic Metaphase and Anaphase (Canis familiaris)
Mitotic Anaphase (Canis familiaris)
Separation of Sister Chromatids (Canis familiaris)
Degradation of multiubiquitinated Securin (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Mitotic G2-G2/M phases (Canis familiaris)
G2/M Transition (Canis familiaris)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Canis familiaris)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Proteasome-mediated degradation of PolyUb-FBXL7 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
The role of GTSE1 in G2/M progression after G2 checkpoint (Canis familiaris)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Regulation of mitotic cell cycle (Canis familiaris)
APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Canis familiaris)
Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC/C:Cdc20 mediated degradation of Securin (Canis familiaris)
Degradation of multiubiquitinated Securin (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Canis familiaris)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Canis familiaris)
Degradation multiubiquitinated Cyclin A (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
S Phase (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Ubiquitin-dependent degradation of Cyclin D (Canis familiaris)
Proteasome mediated degradation of Cyclin D1 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
KEAP1-NFE2L2 pathway (Canis familiaris)
26S proteasome degrades Ub-NFE2L2 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Cellular response to hypoxia (Canis familiaris)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Proteasome proteolyzes ub-HIF-alpha (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
DNA Replication (Canis familiaris)
Synthesis of DNA (Canis familiaris)
Switching of origins to a post-replicative state (Canis familiaris)
CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
Ubiquitinated Cdc6 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Orc1 removal from chromatin (Canis familiaris)
Ubiquitinated Orc1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing-Cross presentation (Canis familiaris)
Cross-presentation of soluble exogenous antigens (endosomes) (Canis familiaris)
Proteasomal clevage of exogenous antigen (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Proteasomal cleavage of substrate (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
Ubiquitinated IkB is degraded (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
TNFR2 non-canonical NF-kB pathway (Canis familiaris)
26Sproteasome degrades K48polyUb-NIK (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
NIK-->noncanonical NF-kB signaling (Canis familiaris)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Dectin-1 mediated noncanonical NF-kB signaling (Canis familiaris)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated NF-kB activation (Canis familiaris)
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Metabolism of polyamines (Canis familiaris)
Regulation of ornithine decarboxylase (ODC) (Canis familiaris)
26S proteosome degrades ODC holoenzyme complex (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Metabolism of RNA (Canis familiaris)
Regulation of mRNA stability by proteins that bind AU-rich elements (Canis familiaris)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Canis familiaris)
AUF1:mRNA complex is destroyed (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Deubiquitination (Canis familiaris)
UCH proteinases (Canis familiaris)
ADRM1 binds 26S proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
ADRM1:26S proteaseome binds UCHL5 (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
ADRM1:26S proteasome:UCHL5 [cytosol] (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Ub-specific processing proteases (Canis familiaris)
ADRM1:26S proteaseome binds USP14 (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
ADRM1:26S proteasome:USP14 [cytosol] (Canis familiaris)
ADRM1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Neddylation (Canis familiaris)
26S proteasome degrades HIFalpha (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
26S proteasome degrades Ub-NFE2L2 (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
PTEN Regulation (Canis familiaris)
Regulation of PTEN stability and activity (Canis familiaris)
Proteasome degrades polyubiquitinated PTEN (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
Regulation of RAS by GAPs (Canis familiaris)
NF1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
MAPK6/MAPK4 signaling (Canis familiaris)
MAPK6 is degraded by the 26S proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog 'off' state (Canis familiaris)
Degradation of GLI1 by the proteasome (Canis familiaris)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
GLI3 is processed to GLI3R by the proteasome (Canis familiaris)
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Hedgehog 'on' state (Canis familiaris)
ub-GLI is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Hedgehog ligand biogenesis (Canis familiaris)
Hh C-terminal fragments are degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
PCP/CE pathway (Canis familiaris)
Asymmetric localization of PCP proteins (Canis familiaris)
PRICKLE1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Degradation of beta-catenin by the destruction complex (Canis familiaris)
Degradation of ubiquitinated beta catenin by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
TCF dependent signaling in response to WNT (Canis familiaris)
Degradation of AXIN (Canis familiaris)
Ub-RibC-AXIN is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Ubiquitinated AXIN is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Degradation of DVL (Canis familiaris)
Ubiquitinated DVL1 is degraded by the proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
misfolded CFTR is degraded by the 26S proteasome (Canis familiaris)
26S proteasome [cytosol] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
Ghost homologue of PSMB11 [cytosol]
(Canis familiaris)
Ghost homologue of PSMB4 [cytosol]
(Canis familiaris)
Ghost homologue of PSME3 [cytosol]
(Canis familiaris)
Ghost homologue of SEM1 [cytosol]
(Canis familiaris)
Homologues of PSMA6 [cytosol]
(Canis familiaris)
LOC100687259 [cytosol]
(Canis familiaris)
LOC610717 [cytosol]
(Canis familiaris)
PSMA1 [cytosol]
(Canis familiaris)
PSMA2 [cytosol]
(Canis familiaris)
PSMA3 [cytosol]
(Canis familiaris)
PSMA4 [cytosol]
(Canis familiaris)
PSMA5 [cytosol]
(Canis familiaris)
PSMA7 [cytosol]
(Canis familiaris)
PSMA8 [cytosol]
(Canis familiaris)
PSMB1 [cytosol]
(Canis familiaris)
PSMB10 [cytosol]
(Canis familiaris)
PSMB2 [cytosol]
(Canis familiaris)
PSMB3 [cytosol]
(Canis familiaris)
PSMB5 [cytosol]
(Canis familiaris)
PSMB6 [cytosol]
(Canis familiaris)
PSMB7 [cytosol]
(Canis familiaris)
PSMB8 [cytosol]
(Canis familiaris)
PSMB9 [cytosol]
(Canis familiaris)
PSMC1 [cytosol]
(Canis familiaris)
PSMC2 [cytosol]
(Canis familiaris)
PSMC3 [cytosol]
(Canis familiaris)
PSMC4 [cytosol]
(Canis familiaris)
PSMC5 [cytosol]
(Canis familiaris)
PSMD1 [cytosol]
(Canis familiaris)
PSMD10 [cytosol]
(Canis familiaris)
PSMD11 [cytosol]
(Canis familiaris)
PSMD12 [cytosol]
(Canis familiaris)
PSMD13 [cytosol]
(Canis familiaris)
PSMD14 [cytosol]
(Canis familiaris)
PSMD2 [cytosol]
(Canis familiaris)
PSMD3 [cytosol]
(Canis familiaris)
PSMD4 [cytosol]
(Canis familiaris)
PSMD6 [cytosol]
(Canis familiaris)
PSMD7 [cytosol]
(Canis familiaris)
PSMD8 [cytosol]
(Canis familiaris)
PSMD9 [cytosol]
(Canis familiaris)
PSME1 [cytosol]
(Canis familiaris)
PSME2 [cytosol]
(Canis familiaris)
PSME4 [cytosol]
(Canis familiaris)
PSMF1 [cytosol]
(Canis familiaris)
Participates
as a component of
ADRM1:26S proteasome [cytosol] (Canis familiaris)
NEDD8,UBD:NUB1:26S proteasome [cytosol] (Canis familiaris)
as an input of
ADRM1 binds 26S proteasome (Canis familiaris)
NEDD8 and UBD bind NUB1 and the 26S proteasome (Canis familiaris)
as an output of
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates (Canis familiaris)
Inferred From
26S proteasome [cytosol]
(Homo sapiens)
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