Reactome | ORC5 [nucleoplasm]

ORC5 [nucleoplasm]

Stable Identifier

R-CFA-68516

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

ORC5, A0A8I3S2I6

Locations in the PathwayBrowser

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Cell Cycle (Canis familiaris)

- Cell Cycle Checkpoints (Canis familiaris)
  - G2/M Checkpoints (Canis familiaris)
    - Activation of ATR in response to replication stress (Canis familiaris)
      - Activation of claspin (Canis familiaris)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
      - Loading of claspin onto DNA during replication origin firing (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
- Cell Cycle, Mitotic (Canis familiaris)
  - Mitotic G1 phase and G1/S transition (Canis familiaris)
    - G1/S Transition (Canis familiaris)
      - Activation of the pre-replicative complex (Canis familiaris)
        
        Cdc45 associates with the pre-replicative complex at the origin (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        Cdt1 is displaced from the pre-replicative complex (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        MCM10:pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        DNA polymerase alpha:primase binds at the origin (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        DNA polymerase epsilon binds at the origin (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
  - S Phase (Canis familiaris)
    - Synthesis of DNA (Canis familiaris)
      - Switching of origins to a post-replicative state (Canis familiaris)
        
        Orc1 removal from chromatin (Canis familiaris)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)

DNA Replication (Canis familiaris)

- DNA Replication Pre-Initiation (Canis familiaris)
  - Activation of the pre-replicative complex (Canis familiaris)
    - Cdc45 associates with the pre-replicative complex at the origin (Canis familiaris)
      - CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
    - Cdt1 is displaced from the pre-replicative complex (Canis familiaris)
      - MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
      - MCM10:pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
    - DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Canis familiaris)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
    - DNA polymerase alpha:primase binds at the origin (Canis familiaris)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
    - DNA polymerase epsilon binds at the origin (Canis familiaris)
      - CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Canis familiaris)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        active pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
  - Assembly of the pre-replicative complex (Canis familiaris)
    - Assembly of the ORC complex at the origin of replication (Canis familiaris)
      - Formation of ORC(1-5) complex (Canis familiaris)
        
        ORC(1-5):origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC(1-5) [nucleoplasm] (Canis familiaris)
        
        ORC(2-5) [nucleoplasm] (Canis familiaris)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC(2-5) [nucleoplasm] (Canis familiaris)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
      - Formation of ORC(1-6) complex (Canis familiaris)
        
        ORC(1-5):origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC(1-5) [nucleoplasm] (Canis familiaris)
        
        ORC(2-5) [nucleoplasm] (Canis familiaris)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC(1-6):origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC(1-5):origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC(1-5) [nucleoplasm] (Canis familiaris)
        
        ORC(2-5) [nucleoplasm] (Canis familiaris)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
      - Formation of ORC(2-5) complex (Canis familiaris)
        
        ORC(2-5) [nucleoplasm] (Canis familiaris)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
      - ORC5 binds ORC2:ORC3 (Canis familiaris)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
    - CDC6 association with the ORC:origin complex (Canis familiaris)
      - CDC6 association with ORC(1-6) at replication origins (Canis familiaris)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC(1-6):origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC(1-5):origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC(1-5) [nucleoplasm] (Canis familiaris)
        
        ORC(2-5) [nucleoplasm] (Canis familiaris)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC(1-6):origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC(1-5):origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC(1-5) [nucleoplasm] (Canis familiaris)
        
        ORC(2-5) [nucleoplasm] (Canis familiaris)
        
        ORC2:ORC3:ORC5 [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
- Synthesis of DNA (Canis familiaris)
  - Switching of origins to a post-replicative state (Canis familiaris)
    - Orc1 removal from chromatin (Canis familiaris)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Canis familiaris)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)
        
        pre-replicative complex [nucleoplasm] (Canis familiaris)
        
        CDT1:CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        CDC6:ORC:origin complex [nucleoplasm] (Canis familiaris)
        
        ORC:origin of replication [nucleoplasm] (Canis familiaris)
        
        ORC5 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S2I6

Gene Names

ORC5

Reference Genes

ENSEMBL:ENSCAFG00845017129.1

UCSC:A0A8I3S2I6 ORC5

Other Identifiers

609937

Cfa.16807.1.S1_at

CfaAffx.7143.1.S1_s_at

GO:0000166

GO:0000785

GO:0000808

GO:0005524

GO:0005634

GO:0005654

GO:0005664

GO:0005829

GO:0006260

GO:0006270

GO:0006275

Participates

as a component of

as an input of

ORC5 binds ORC2:ORC3 (Canis familiaris)

Inferred From

ORC5 [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFP00845023899, ENSCAFT00845030467, ENSCAFG00845017129

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